Comparative Physiology of Platelets from Different Species

  • Douglas J. Weiss

Abstract

The mammalian blood platelet contributes to hemostasis as a result of its ability to adhere to exposed subendothelial collagen and to respond to stimuli, including, thromobin and adenosine diphosphate, with formation of platelet aggregates. In general, platelets from companion and food-producing animals, and rodents have similar morphology but vary considerably in size (Clemmons et al. 1983). Platelet volume varies from large (15.1 fl) in cats, to intermediate (7.6 to 8.3 fl) in pig and dog, to small (3.2 to 5.4 fl) in cattle, horse, sheep, rat, guinea pig, and mouse (Jain 1993). With few exceptions, platelets of various species contain a plasma membrane, circumfrential microtubular system, mitochondria, alpha granules, dense bodies, glycogen granules, and an open canalicular system. However, ruminant platelets lack an organized microtubular system and an open canalicular system. Species differences in the number and relative abundance of membrane glycoproteins occur.

Keywords

Aspirin Pancreatitis Histamine Smoke Cardiomyopathy 

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References

  1. Addonizio VP, Edmunds LH, Coleman RW. The function of monkey (M. mulatta) platelets compared to platelets of pig, sheep, and man. J Lab Clin Med 1978;91:989–997Google Scholar
  2. Bondy GS, Gentry PA. Characteristics of the normal bovine platelet aggregation response. Comp Biochem Physiol 1989;92C:67–72Google Scholar
  3. Boudreaux MK, Wagner-Mann C, Purohit R, Hankes G, Spano J, Pablo L, Lee S, Conti J. Platelet function testing in the pony. Lab Animal Sci 1988;38:448–451Google Scholar
  4. Bordeaux MK, Weiss RC, Toivio-Kinnucan, Cox N, Spano JS. Enhanced platelet reactivity in cats experimentally infected with feline infectious peritonitis virus. Vet Pathol 1990;27:269–273Google Scholar
  5. Boudreaux MK, Crager C, Dillon AR, Stanz K, Toivio-Kinnucan M. Identification of an intrinsic platelet function defects in Spitz dogs. J Vet Intern Med 1994;8:93–98CrossRefGoogle Scholar
  6. Boudreaux MK, Platelets and coagulation: an update. Vet Clin North Am 1996a;26:1065–1083Google Scholar
  7. Boudreaux MK, Kvam K, Dillon AR, Bourne C, Scott M, Schwartz KA, Toivio-Kinnucan. Type I Glanzman’s thrombasthenia in a Great Pyrinees dog. Vet Pathol 1996;33:503–511CrossRefGoogle Scholar
  8. Callan MB, Bennett JS, Phillips DK, Haskins ME, Hayden JE, Anderson JG, Giger U. Inherited platelet deltastorage pool disease causing severe bleeding: An animal model for a specific ADP deficiency. Thrombosis and Haemostasis 1995;74:949–953Google Scholar
  9. Catalfamo JL, Raymond SL, White JG, Dodds J. Defective platelet-fibrinogen interaction in hereditary canine thrombopathy. Blood 1986;67:1568–1577Google Scholar
  10. Cheryk LA, Gentry PA, Tablin F. Morphological characteristics of bovine platelets activated with platelet-activating factor or thrombin. Comparat Haematol Inter 1997;7:88–95CrossRefGoogle Scholar
  11. Gemmons RM, Bliss EL, Dorsey-Lee MR, Deachord CL, Meyers KM. Platelet function, size, and yeild in whole blood and in platelet-rich plasma prepared uising differing centrifugation force and time in domestic and food-producing animals. Thrombo Haemostas 1983;50:838–843Google Scholar
  12. Daniels TD, Fass DN, White JG, Bowie EJW. Platelet storage pool deficiency in pigs. Blood 1986;67:1043–1047Google Scholar
  13. Dodds WJ, Moynihan AC, Fischer TM. The frequency of inherited blood and eye diseases as determined by genetic screening programs. J Am Anim Hosp Assoc 1981; 17:697–704Google Scholar
  14. Duncan SG, Meyers KM, Reed SM, Grant B. Alterations in coagulation and hemograms of horses given endotoxin for 24 hours via hepatic portal infusion. Am J Vet Res 1985;46:1287–1292Google Scholar
  15. Dwyer SD, Meyers KM. Anesthetics and anticoagulants used in the preparation of rat platelet-rich plasma alter rat platelet aggregation. Thrombosis Res 1986;42:139–151CrossRefGoogle Scholar
  16. Estry DW, Mattson JC, Oesterle JR, Mahoney GJ, Patterson WR. Bassett hound hereditary thrombopathy — an inherited disorder with defective platelet aggregation despite normal fibrinogen binding and receptor mobility. Compar Haematol Inter 1995;5:227–236CrossRefGoogle Scholar
  17. Fass DN, Brockway WJ, Owen CA, Bowie EJW. Factor VIII (Willebrand) antigen and ristocetin-Willebrand factor in pigs with von Willebrand’s disease. Thrombosis Res 1976;8:319–327CrossRefGoogle Scholar
  18. Feingold HM, Pivacek LE, Melaragno AJ, Valeri R. Coagulation assays and platelet aggregation patterns in human, baboon, and canine blood. Am J Vet Res 1986;47:2197–2199Google Scholar
  19. Frojmovic MM, Wong T, Searcy GP. Platelets from bleeding Simmental cattle have a long delay in both ADP-activated expression of GPIIbIIIa receptors and fibrinogen-dependent platelet aggregation. Thrombosis and Haemostasis 1996;76:1047–1052Google Scholar
  20. Grouse LH, Rao GH, Weiss DJ, Perman V, White JG. Surface-activated bovine platelets do not spread, they unfold. Am J Pathol 1990;136:399–408Google Scholar
  21. Harms S, Waner T, Eldor A, Zwang E, Bark H. Platelet dysfunction associated with experimental acute canine ehrlichiosis. Vet Ree 1996;139:290–293CrossRefGoogle Scholar
  22. Heath MF, Evans RJ, Poole AW, Hayes LJ, McEvoy RJ, Littler RM. The effects of aspirin and paracxetamol on the aggregation of equine blood platelets. J Vet Pharmacol Therap 1994;17:374–378CrossRefGoogle Scholar
  23. Helenski CA, Ross JN. Platelet aggregation in feline cardiomyopathy. J Vet Intern Med 1987;1:24–28CrossRefGoogle Scholar
  24. Holland JM. Serotonin deficiency and prolonged bleeding time in beige mice (39137). Proc Soc Exp Biol Med 1976;151:32–39Google Scholar
  25. Jain, Nemi. Essentials of Veterinary Hematology. Philadelphia: Lea & Febiger, 1993.Google Scholar
  26. Jarvis GE, Evans RJ. Endotoxin-induced platelet aggregation in heparinized equine whole blood in vitro. Res Vet Sci 1994;57:317–324CrossRefGoogle Scholar
  27. Jarvis GE, Evans RJ. Platelet-activating factor and not thromboxane A (2) is an important mediator of endotoxininduced platelet aggregation in equine heparinized whole blood in vitro. Blood Coag & Fibrinolysis 1996;7:194–198CrossRefGoogle Scholar
  28. Johnstone IB, Viel L, Crane S, Whiting T. Hemostatic studies in racing standardbred horses with exerciseinduced pulmonary hemorrhage. Hemostatic parameters at rest and after moderate exercise. Can J Vet Res 1991;55:101–106Google Scholar
  29. Johnson GS, Turrentine MA, Kraus KH. Canine von Willebrand’s disease: a heterogeneous group of bleeding disorders. Vet Clin North Amer 1988;18:195–229Google Scholar
  30. Lapetina EG, Cuatrecasas P. Stimulation of phosphatadic acid production in platelets produces the formation of arachidonate and parallels the release of serotonin. Biochem Biophys Acta 1979;573:394–401CrossRefGoogle Scholar
  31. Lapetina EG. Regulation of arachidonic acid production: role of phospholipase C and A2. Trends Pharmacol 1982;115–119Google Scholar
  32. Leysen JE, Gommeren W, DeClerck F. Demonstration of S2-receptor binding sites on cat blood platelets using [3H] Kaiserin. Euro J Pharmacol 1983;88:125–134CrossRefGoogle Scholar
  33. Maxwell MH. An ultrastructural comparison of the mononuclear leukocytes and thrombocytes in six species of domestic bird. J Anat 1974;117:69–80.Google Scholar
  34. McKeller QA, Nolan AM, Galbraith EA. Serum thromboxane generation by platelets in several domestic species. Brit Vet J 1990;146:398–404CrossRefGoogle Scholar
  35. Menard M, Meyers KM, Prieur DJ. Primary and secondary lysosomes in megakaryocytes and platelets of cattle with the Chediak-Higashi syndrome. Throm Haemostasis 1990;64:156–160Google Scholar
  36. Meyers KM, Pierce KR, Gowing GM. Hemorrhagic diathesis resembling pseudohemophilia in a dog. 1972;161:1028–1029Google Scholar
  37. Meyers KM, Katz JB, Gemmons RM, Smith JB, Holmsen H. An evaluation of the arachadonate pathway of platelets from companion and food-producing animals, mink, and man. Thrombosis Res 1980;20:13–24CrossRefGoogle Scholar
  38. Meyers KM, Seachord CL, Holmsen H, Prieur DJ. Evaluation of the platelet storage pool deficiency in the feline counterpart of Chediak-Higashi syndrome. Am J Hematol 1981;11:241–248CrossRefGoogle Scholar
  39. Meyers KM. “Species Differences” in Platelet Responses and Metabolism, H Holmsen, ed. Boca Raton Fl: CRC Press pp 209–227, 1986.Google Scholar
  40. Meyers KM, Lindner C, Grant B. Characterization of the equine platelet aggregation response. Am J Vet Res 1979;40:260–264Google Scholar
  41. Meyers, Kenneth and Wardrop, K. Jane. “Platelets and Coagulation.” In Comparative Transfusion Medicine, Susan M. Cotter, ed. New York: Academic Press, 1991.Google Scholar
  42. MoComell MF, Thomas JS, Dipinto MN, Bell TG. Circumvention of the Basset hound hereditary thrombopathy by platelet activation with phorbol myristate acetate. Platelets 1995;6:131–138CrossRefGoogle Scholar
  43. Miura N, Senba H, Ogawa H, Sasaki N, Oishi H, Fumihito F, Takeuchi A, Usui K. A case of equine thrombasthenia. Jpn J Vet Sci 1987;49:155–158CrossRefGoogle Scholar
  44. Morrison DC, Kline LF, Oades ZG. Mechanisms of lipopolysaccharide-initiated rabbit platelet responses. Infect Immun 1978;20:744–751Google Scholar
  45. Nurden AT, Butcher PD, Hawkey CM. Comparative studies on the glycoprotein composition of mammalian platelets. Comp Biochem Physiol 1977; 89:407–413Google Scholar
  46. Owens CA, Bowie EJW, Zollman PE, Fass DN, Gordon H. Carriers of porcine von Willebrand’s disease. Am J Vet Res 1974;35:245–248Google Scholar
  47. Rosenblum WI, Nelson GH, Cockrell CS, Ellis EF. Some properties of mouse platelets. Thrombosis Res 1983;30:347–355CrossRefGoogle Scholar
  48. Searcy GP, Sheridan D, Dobson KA. Preliminary studies of a platelet function disorder in simmental cattle. Can J Vet Res 1990;54:394–396Google Scholar
  49. Sinakos Z, Caen JP. Platelet aggregation in mammalians (human, rat, rabbit, guinea-pig, horse, dog) a comparative study. Thrombosis and Haemostasis 1967; 17: 99–111Google Scholar
  50. Shinozaki K, Kawasaki T, Kambayashi J, Sakon M, Shiba E, Ou M, Mori T. Species differences in platelet aggregation induced by platelet-activating factor (PAP). Meth Find Exp Clin Pharmacol 1992;14:663–665Google Scholar
  51. Suequet CM, Leid RW. Aggregation of equine platelets by PAF (platelet-activating factor). Inflammation 1983;7:197–203CrossRefGoogle Scholar
  52. Thomas JS. Comparison of platelet aggregation and adenosine triphosphate secretion in whole blood and plateletrich plasma from normal dogs. Compar Haematol Inter 1996;6:70–76CrossRefGoogle Scholar
  53. Tschopp TB. Aggregation of cat platelets in vitro. Thromb Diath Haemorrh 1970;23:601–620Google Scholar
  54. Tschoff TB, Zucker MB. Hereditary defects in platelet function in rats. Blood 1972;40:217–225Google Scholar
  55. Weiss DJ, Smith CM, Rao GH, White JG. Platelet function in the racing Thoroughbred: implications for exercise-induced pulmonary hemorrhage. Vet Clin Path 1990; 19:35–39CrossRefGoogle Scholar
  56. Weiss DJ, Geor RJ, Johnston G, Trent A. Microvascular thrombosis associated with onset of acute laminitis in ponies. Am J Vet Res 1994;55:606–612Google Scholar
  57. Weiss DJ, Trent AM, Johnston G. Prothrombotic events in the prodromal stages of acute laminitis in horses. Am J Vet Res 1995;56:986–991Google Scholar
  58. Weiss DJ, Evanson OA, Wells RE. Evaluation of arginine-glycine-aspartate-containing peptides as inhibitors of equine platelets function. Am J Vet Res 1997a;58:457–460Google Scholar
  59. Weiss DJ, Evanson OA, McClenahan D, Fagliari JJ. Evaluation of platelet activation and platelet-neutrophil aggregates in ponies with alimentary laminitis. Am J Vet Res 1997b;58:1376–1380Google Scholar
  60. Weiss DJ, Evanson OA, Fagliari JJ, Valberg S. Evaluation of platelet activation and platelet-neutrophil aggregates in Thoroughbreds undergoing near-maximal treadmill exercise. Am J Vet Res (in press)Google Scholar
  61. Weiss DJ, Evanson OA, McClenahan D, Fagliari JJ, Dunnwiddie CT, Wells RE. A competitive inhibitor of platelet aggregation prevents experimental equine laminitis. Am J Vet Res (in press)Google Scholar
  62. Welles EG, Boudreaux MK, Tyler JW. Platelet antithrombin, and fibrinolytic activities in taurine-déficient and taurine-replete cats. Am J Vet Res 1993;54:1235–1242Google Scholar
  63. White JG, Matlack KL, Mundschenk D, Rao GHR. “Platelet studies in normal and a bleeder horse.” In First international symposium on equine hematology, H. Kitchen and JD Krehbiel ed. Golden Co, 1976.Google Scholar
  64. White JG. The secretory pathway of bovine platelets. Blood 1987;69:878–885Google Scholar
  65. Willis SE, Jackson ML, Meric SM, Rousseaux CG. Whole blood platelet aggregation in dogs with liver disease. Am J Vet Res 1989;50:1893–1896Google Scholar
  66. Zucker-Franklin D Benson KA, Meyers KM. Absence of a surface-connecting canalicular system in bovine platelets. Blood 1985;65:241–244Google Scholar

Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Douglas J. Weiss
    • 1
  1. 1.Department of Pathobiology School of Veterinary SciencesUniversity of MinnesotaSt. Paul.USA

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