Comparative Physiology of Platelets from Different Species

  • Douglas J. Weiss


The mammalian blood platelet contributes to hemostasis as a result of its ability to adhere to exposed subendothelial collagen and to respond to stimuli, including, thromobin and adenosine diphosphate, with formation of platelet aggregates. In general, platelets from companion and food-producing animals, and rodents have similar morphology but vary considerably in size (Clemmons et al. 1983). Platelet volume varies from large (15.1 fl) in cats, to intermediate (7.6 to 8.3 fl) in pig and dog, to small (3.2 to 5.4 fl) in cattle, horse, sheep, rat, guinea pig, and mouse (Jain 1993). With few exceptions, platelets of various species contain a plasma membrane, circumfrential microtubular system, mitochondria, alpha granules, dense bodies, glycogen granules, and an open canalicular system. However, ruminant platelets lack an organized microtubular system and an open canalicular system. Species differences in the number and relative abundance of membrane glycoproteins occur.


Aggregation Response Rabbit Platelet Feline Infectious Peritonitis Alpha Granule Platelet Structure 
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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Douglas J. Weiss
    • 1
  1. 1.Department of Pathobiology School of Veterinary SciencesUniversity of MinnesotaSt. Paul.USA

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