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Stem Cell Collection for Hematopoietic Transplantation: Stem Cell Sources, Mobilization Strategies, and Factors that Influence Yield

  • Chapter
Book cover Clinical Applications of Cytokines and Growth Factors

Part of the book series: Developments in Oncology ((DION,volume 80))

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Abstract

Over the past decade, it has become clear that the make-up of the stem cell product used in hematopoietic transplantation is one of the most important determinants of transplant outcome. The number of hematopoietic progenitor cells (HPC) is the major determinant of the speed of hematopoietic reconstitution and thereby a strong influence on the length of transplant hospitalization, the amount of resources needed to provide supportive care for the period of iatrogenic marrow failure, and the risk of treatment-related mortality. Both numbers and types of immune cells in the stem cell product also influence the speed and potency of immune reconstitution and the ability of the patient to withstand assault from opportunistic pathogens. In the case of an autologous hematopoietic transplant, contamination by tumor cells admixed with hematopoietic progenitors is strongly associated with the risk for recurrence of the disease for which the transplant is used. In the case of allogeneic hematopoietic transplantation, the presence of large numbers of T lymphocytes influences the risk for graft-versus-host disease (GVHD). With these observations in mind, a number of investigators have evaluated methods to enumerate HPCs, quantify and characterize immune cells, identify presence and number of contaminating tumor cells, and characterize what factors influence the yield of hematopoietic progenitors in the stem cell product.

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  1. John R. Wingard
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  2. Frederick M. Weeks
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Editors and Affiliations

  1. Bone Marrow Transplant Program, Division of Hematology/Oncology, University of Florida College of Medicine, Shands Hospital, Gainesville, FL, 32610, USA

    John R. Wingard M.D. (Professor of Medicine, Director) (Professor of Medicine, Director)

  2. Department of Adult Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, 02115, USA

    George D. Demetri M.D. (Assistant Professor of Medicine) (Assistant Professor of Medicine)

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Wingard, J.R., Weeks, F.M. (1999). Stem Cell Collection for Hematopoietic Transplantation: Stem Cell Sources, Mobilization Strategies, and Factors that Influence Yield. In: Wingard, J.R., Demetri, G.D. (eds) Clinical Applications of Cytokines and Growth Factors. Developments in Oncology, vol 80. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5013-6_19

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