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Chemotherapy and Biological Therapy of Thyroid Cancer

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Thyroid Cancer

Part of the book series: Endocrine Updates ((ENDO,volume 2))

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Abstract

Anaplastic carcinoma of the thyroid is one of the most aggressive cancers encountered in humans. It is a rare disease that occurs in elderly patients. In most cases, it represents the terminal stage in the dedifferentiation of a follicular or papillary carcinoma. In fact, anaplastic cells do not produce thyroglobulin, they are not able to transport iodine and thyrotropin (TSH) receptors are not found in their plasma cell membranes. Radioiodine treatment is useless in cases with an anaplastic component, even when it represents a small proportion of the tumor.

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References

  1. Nel C.J.C., Van Heerden J.A., Goellner J.R., Gharib H., Mc Conahey W.M., Taylor W.F., Grant C.S. Anaplastic carcinoma of the thyroid: a clinicopathologic study of 82 cases. Mayo Clin Proc 1985; 60:51–58.

    PubMed  CAS  Google Scholar 

  2. Venkatesh Y.S.S., Ordonez N.G., Schultz P.N., Hickey R.C., Goepfert H., Samoan N.A. Anaplastic carcinoma of the thyroid A clinicopathologic study of 121 cases. Cancer 1990; 66: 321–330.

    Article  PubMed  CAS  Google Scholar 

  3. Tubiana M., Haddad E., Schlumberger M., Hill C., Rougier P., Sarrazin D. External radiotherapy in thyroid cancers. Cancer 1985; 55:2062–2071.

    Article  PubMed  CAS  Google Scholar 

  4. Shimaoka K., Schoenfeld D.A., De Wys W.D., Creech R.H., De Conti R. A randomized trial of Doxorubicin versus Doxorubicin plus Cisplatin in patients with advanced thyroid carcinoma. Cancer 1985; 56:2155–2160.

    Article  PubMed  CAS  Google Scholar 

  5. Kim J.H., Leeper R.D. Treatment of locally advanced thyroid carcinoma with combination Doxorubicin and radiation therapy. Cancer 1987; 60:2372–2375.

    Article  PubMed  CAS  Google Scholar 

  6. Tennvall J., Lundell G., Hallquist A., Wahlberg P., Wallin G., Tibblin S. and the Swedish Anaplastic Thyroid Cancer Group. Combined doxorubicin, hyperfractionated radiotherapy, and surgery in anaplastic thyroid carcinoma. Cancer 1994; 74:1348–1354.

    Article  PubMed  CAS  Google Scholar 

  7. Tallroth E., Wallin G., Lundell G, Lŏwhagen T., Einhorn J. Multimodality treatment in anaplastic giant cell thyroid carcinoma. Cancer 1987; 60:1428–1431.

    Article  PubMed  CAS  Google Scholar 

  8. Schlumberger M., Parmentier C., Delisle M.J., Couette J.E., Droz J.P., Sarrazin D. Combination therapy for anaplastic giant cell thyroid carcinoma. Cancer 1991; 67:564–566.

    Article  PubMed  CAS  Google Scholar 

  9. Matsuzuka F., Miyauchi A., Katayama S., Narabayashi I., Ikeda H., Kuma K., Sugawara M. Clinical aspects of primary thyroid lymphoma: diagnosis and treatment based on our experience of 119 cases. Thyroid 1993; 3:93–99.

    Article  PubMed  CAS  Google Scholar 

  10. Doria R., Jekel J.F., Cooper D.L. Thyroid lymphoma: the case for combined modality therapy. Cancer 1994; 73:200–206.

    Article  PubMed  CAS  Google Scholar 

  11. Gottlieb J.A., Hill C.S. Adriamycin (NSC - 123 127) therapy in thyroid carcinoma. Cancer Chemother, Rep 1975; 6:283–296.

    Google Scholar 

  12. Droz J.P., Schlumberger M., Rougier P., Ghosn M., Gardet P., Parmentier C. Chemotherapy in metastatic nonanaplastic thyroid cancer: experience at the Institut Gustave-Roussy. Tumori 1990; 76:480–483.

    PubMed  CAS  Google Scholar 

  13. Hoskin P.J., Harmer C. Chemotherapy for thyroid cancer. Radiother Oncol 1987; 10:187–194.

    Article  PubMed  CAS  Google Scholar 

  14. Williams S.D., Birch R., Einhorn L.H. Phase II evaluation of doxorubicin plus cisplatin in advanced thyroid cancer: a Southeastern Cancer Study Group Trial. Cancer Treat. Rep. 1986; 70:405–407.

    CAS  Google Scholar 

  15. Magee M.J., Howard J., Bosl G.J., Wittes R.E. Phase II trial of 4’-epidoxorubicin in advanced carcinoma of head and neck origin. Cancer Treat. Rep. 1985; 69:125–126.

    PubMed  CAS  Google Scholar 

  16. Zlock D.W., Greenspan F.S., Clark O.H., Higgins C.B. Octreotide therapy in advanced thyroid cancer. Thyroid 1994; 4: 427–431.

    Article  PubMed  CAS  Google Scholar 

  17. Van Herle A.J., Agatep M.L., Padua Iii D.N., Totanes T.L., Canlapan D.V., Van Herle H.M. Effects of 13 cis-retinoic acid on growth and differentiation of human follicular carcinoma cells (UCLA RO 82 W-1) in vitro. J Clin Endocrinol Metab 1990; 71:755–763.

    Article  PubMed  Google Scholar 

  18. Arai M., Tsushima T., Isozaki O., Shizume K., Emoto N., Demura H., et al. Effects of retinoids on iodine metabolism, thyroid peroxydase gene expression, and deoxyribonnucleic acid synthesis in porcine thyroid cells in culture. Endocrinology 1991; 129:2827–2833.

    Article  PubMed  CAS  Google Scholar 

  19. Schreck R., Schnieders F., Schmutzler C., Koehrle J. Retinoids stimulate type I iodothyronine 5’deiodinase activity in human follicular thyroid carcinoma cell lines. J Clin Endocrinol Metab 1994; 79:791–798.

    Article  PubMed  CAS  Google Scholar 

  20. Börner A.R., Simon D. Isotretinoin in metastatic thyroid cancer. Ann Int Med 1997; 127:246.

    PubMed  Google Scholar 

  21. Challeton C, Bounacer A, Duvillard JA, Caillou B, De Vathaire F, Monier R, Schlumberger M, Suarez HG. Pattern of ras and gsp oncogene mutations in radiation-associated human thyroid tumors. Oncogene 1995; 11:601–603.

    PubMed  CAS  Google Scholar 

  22. Jackson J.H., Cochrane C.G., Bourne J.R., Solski P.A., Buss J.E., Der C.J. Famesyl modification of Kirsten-ras exon 4B protein is essential for transformation. Proc Natl Acad Sci. 1990; 87: 3042–3046.

    Article  PubMed  CAS  Google Scholar 

  23. Gibbs J.B., Oliff A., Kohl N.E. Farnesyltransferase inhibitors: ras research yields a potential cancer therapeutic. Cell. 1994; 77:175–178.

    Article  PubMed  CAS  Google Scholar 

  24. Husain M., Alsever R.N., Lock J.P., George W.F., Katz F.H. Failure of medullary carcinoma to respond to doxorubicin therapy. Hormone Res. 1978; 9:22–25.

    Article  PubMed  CAS  Google Scholar 

  25. Leight G.S., Farrel R.E., Wells S.A., Falletta J.M Effects of chemotherapy on calcitonin (CT) levels in patients with metastatic medullary thyroid carcinoma (MTC). Proc Ann Meet Am Assoc Cancer Res 1980; 21:622.

    Google Scholar 

  26. Kamalakar P., Freeman A.I., Higby D.J., Wallace H.J., Sinks L.F. Clinical response and toxicity with cisdichlorodiammineplatinum (II) in children. Cancer Treat Rep. 1977; 61:835–839.

    PubMed  CAS  Google Scholar 

  27. Kelsen D.P., Cheng E., Kemeny N., Magill G.B., Yagoda N. Streptozotocin and adriamycin in the treatment of APUD tumors (carcinoid, islet cell and medullary carcinoma of the thyroid) (Abstr.). Proc Am Assoc Cancer Res. 1982; 111.

    Google Scholar 

  28. Kelsen D., Fiore J., Heelan E., Cheng E, Magill G. Phase II trial of Etoposide in APUD tumors. Cancer Treat Rep. 1987; 71:305–307.

    PubMed  CAS  Google Scholar 

  29. Schlumberger M., Abdelmoumene N., Delisle M.J., Couette J.E. and the Groupe d’Etude des Tumeurs à Calcitonine (GETC). Treatment of advanced medullary thyroid cancer with an alternating combination of 5 FU-streptozocin and 5 FU-dacarbazine. Br J Cancer. 1995; 71:363–365.

    Article  PubMed  CAS  Google Scholar 

  30. Petursson S.R. Metastatic medullary thyroid carcinoma. Complete response to combination chemotherapy with dacarbazine and 5-fluorouracil. Cancer. 1988; 62:1899–1903.

    Article  PubMed  CAS  Google Scholar 

  31. Orlandi F., Caraci P., Berruti A., Puligheddu B., Pivano G., Dogliotti L., Angeli A. Chemotherapy with dacarbazine and 5-fluorouracil in advanced medullary thyroid cancer. Ann Oncol. 1994; 5:763–765.

    PubMed  CAS  Google Scholar 

  32. Wu L.T., Averbuch S.D., Ball D.W., de Bustros A., Baylin S.B., McGuire W.P. Treatment of advanced medullary thyroid carcinoma with a combination of cyclophosphamide, vincristine and dacarbazine Cancer. 1994; 73:432–436.

    Article  PubMed  CAS  Google Scholar 

  33. Burgess MA, Sellin RV, Gagel RP. Chemotherapy for metastatic medullary carcinoma of the thyroid (MTC) with doxorubicin, imidazole carboxamide (DTIC), vincristine (VCR) and cyclophosphamide (CPA). ASCO, 1995.

    Google Scholar 

  34. Weber C.J., Marvin M., Krekun S., Koschitzky T., Karp F., Benson M., Feind C.R. Effects of tamoxifen and somatostatin on growth of human medullary, follicular and papillary thyroid. carcinoma cell lines: tissue culture and nude mouse xenograft studies. Surgery. 1990; 109:1065–1071.

    Google Scholar 

  35. Garcia Pascual E.L., Millan M., Aglada J., Garau J. Tamoxifen failure in medullary thyroid carcinoma. Tumori. 1993; 79:357–358.

    PubMed  CAS  Google Scholar 

  36. Mahler C., Verhelst J., de Longueville M., Hams A. Long term treatment of metastatic thyroid carcinoma with the somatostatin analog octreotide. Clin Endocrinol. 1990; 33:261–269.

    Article  CAS  Google Scholar 

  37. Modigliani E., Cohen R., Joannidis S., Siame-Mourot C., Guliana J.M., Charpentier G., Cassuto D., Bentata-Pessayre M., Tabarin A., Roger P., Caron P., Guillausseau P.J., Lalau J.D., Toumiaire J., Bayard F., Aufevre P., James-Deidier A., Calmettes C. Result of long-term continuous subcutaneous octreotide administration in 14 patients with medullary thyroid carcinoma. Clin Endocrinol. 1992; 36:183–186.

    Article  CAS  Google Scholar 

  38. Lupoli G., Cascone E., Arlotta F., Vitale G., Celentano L., Salvatore M., Lombardi G. Treatment of advanced medullary thyroid carcinima with a combination of recombinant interferon ?-2b and octreotide. Cancer. 1995; 78:1114–1118.

    Article  Google Scholar 

  39. Bardiès M., Bardet S., Faivre-Chauvet A., Peltier P., Douillard J.Y., Mahé M., Fiche M., Lisbona A., Giacalone F., Meyer P., Gautherot E., Touvier E., Barbet J., Chatal J.-F. Bispecific antibody and iodine-131-labeled bivalent hapten dosimetry in patients with medullary thyroid or small-cell lung cancer. J Nucl Med. 1996; 37:1853–1859.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Institut Gustave-Roussy Villejuif, France

    A. F. Cailleux & M. J. Schlumberger

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  1. A. F. Cailleux
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  2. M. J. Schlumberger
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Editors and Affiliations

  1. Division of Endocrinology & Metabolism Department of Medicine College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA

    James A. Fagin

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© 1998 Springer Science+Business Media New York

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Cailleux, A.F., Schlumberger, M.J. (1998). Chemotherapy and Biological Therapy of Thyroid Cancer. In: Fagin, J.A. (eds) Thyroid Cancer. Endocrine Updates, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4945-1_14

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  • DOI: https://doi.org/10.1007/978-1-4615-4945-1_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7244-8

  • Online ISBN: 978-1-4615-4945-1

  • eBook Packages: Springer Book Archive

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