Abstract
Ever since the introduction of dialysis treatment for end-stage renal failure, efforts have been made to define the appropriate dose of blood purification. In this context, “adequacy” is used synonymously with “satisfactory” or “sufficient” and refers to the dose of dialysis below which a significant increase in morbidity and mortality would occur. Thus, dialysis adequacy refers to the minimally acceptable dose of dialysis, and should not be mixed up with “optimal” dialysis, i.e. the dose of blood purification beyond which no further improvement in the patient’s clinical wellbeing can be achieved.
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References
Gotch FA, Sargent JA. A mechanistic analysis of the National Cooperative Dialysis Study (NCDS). Kidney Int 1985; 28:526–534
National Kidney Foundation NKF-DOQI clinical practice guidelines for peritoneal dialysis adequacy. Am J Kidney Dis 1997; 30: S67-67S136
Twardowski ZJ, Nolph KD, Khanna R, Prowant BF, Ryan LP, Moore HL, Nielsen MP. Peritoneal equilibration test. Periton Dial Bull 1987; 7:138–147
Ellis EN, Watts K, Wells TG, Arnold WC. Use of the Peritoneal Equilibration Test in pediatric dialysis patients. Adv Periton Dial 1991;7:259–261
Schröder CH, Van Dreumel MJ, Reddingius R, Theeuwes AG, Willems HL, de Jong MC, Monnens LA. Peritoneal transport kinetics of glucose, urea, and creatinine during infancy and childhood. Perit Dial Int 1991; 12:322–326
Schaefer F, Langenbeck D, Heckert K-H, Schärer K, Mehls O. Evaluation of peritoneal solute transfer by the peritoneal equilibration test in children. Adv Periton Dial 1992; 8:410–415
Geary DF, Harvey EA, Macmillan JH, Goodman Y, Scott M, Balfe JW. The peritoneal equilibration test in children. Kidney Int 1992;42:102–105
Edefonti A, Picca M, Galato R, Guez S, Giani M, Ghio L, Damiani B, Dal Col A, Santeramo C. Evaluation of the peritoneal equilibration test in children on chronic peritoneal dialysis. Perit Dial Int 1993; 13 Suppl 2:S260-260S262
Hanna D, Foreman JW, Gehr TWB, Chan JCM, Wolfrum J, Rudley J. The peritoneal equilibration etst in children. Pediatr Nephrol 1993;7:731–734
Mendley SR, Umans JG, Majkowski NL. Measurement of peritoneal dialysis delivery in children. Pediatr Nephrol 1993;7:284–289
Sliman GA, Klee KM, Gall-Holden B, Watkins SL. Peritoneal equilibration test curves and adequacy of dialysis in children on automated peritoneal dialysis. Am J Kidney Dis 1994; 24:813–818
Fitwater DS, Jones DP. Use of a modified peritoneal equilibration test to optimize solute and water clearance. Pediatr Nephrol 1995;24:813–818
Schaefer F and Mid European Pediatric CAPD/CCPD Study Group. Use of Peritoneal Equilibration est, small or middle molecule clearances and urea kinetic modeling to define the adequacy of peritoneal dialysis in children: experience in a large pediatric population. Pediatr Nephrol 1994; 8:C34
Mendley DS, Majkowski NL. Peritoneal equilibration test results in infants, children, and adults. J Am Soc Nephrol 1995;6:1309–1312
Warady BA, Alexander SB, Hossli S, Vonesh E, Geary D, Watkins S, Salusky IB, Kohaut EC. Peritoneal membrane transport function in children receiving long-term dialysis. J Am Soc Nephrol 1996; 7:2385–2391
Wegner G. Chirurgische Bemerkungen über die Peritonealhöhle mit besonderer Berücksichtigung der Ovariotomie. Arch KlinChir 1877; 20:51
Putiloff PV. Materials for the study of the laws of growth of the human body in relation to the surface areas of different systems; the trial on Russian subjects of Planigraphic anatomy as a means for exact anthropometry — one of the problems of anthropology. Siberian Branch of Russian Geografic Society 1884
Esperanca MJ, Collins DL. Peritoneal dialysis efficiency in relation to body weight. J Pediatr Surg 1966; 1:162–169
Davies SJ, Brown B, Bryan J, Russell GI. Clinical evaluation of the peritoneal equilibration test: a population-based study. Nephrol Dial Transplant 1993; 8:64–70
Trivedi H, Khanna R, Lo WK, Prowant BF, Nolph KD. Reproducibility of the peritoneal equilibration test in CAPD patients. ASAIO J 1994; 40:M892-892M895
Farrell SC, Bailey MP. Measurement of creatinine in peritoneal dialysis fluid. Ann Clin Biochem 1991;28:624–625
Waniewski J, Werynski A, Heimbürger O, Lindholm B. A comparative analysis of mass transfer models in peritoneal dialysis. ASAIO Trans 1991;37:65–75
Heimbürger O, Waniewski J, Werynski A, Park MS, Lindholm B. Dialysate to plasma solute concentrations (D/P) versus peritoneal transport parameters in CAPD. Nephrol Dial Transplant 1994; 9:47–59
Haraldsson B. Assessing the peritoneal dialysis capacities of individual patients. Kidney Int 1995; 47:1187–1198
Rippe B, Stelin G, Haraldsson B. Computer simulations of peritoneal fluid transport in CAPD. Kidney Int 1991;40:315–325
Rippe B. A three-pore model of peritoneal transport. Perit Dial Int 1993; 13 Suppl 2:S35-35S38
Schaefer F, Haas S, Mehls O. Evaluation of dialysis adequacy by peritoneal dialysis capacity test in children on automated peritoneal dialysis. Perit Dial Int 1997; 17 Suppl 1.S88
Hume R. Prediction of lean body mass from height and weight. J Clin Pathol 1966;19:389–391
Watson PE, Watson ID, Batt RD. Total body water volumes for adult males and females estimated from simple anthropometric measurements. Am J Clin Nutr 1980; 33:27–39
Cheek DB, Mellits D, Elliott D. Body water, height, and weight during growth in normal children. Am J Dis Child 1966;112:312–317
Wong KC, Xiong DW, Kerr PG, Borovnicar DJ, Stoud DB, Atkins RC, Strauss BJG. Kt/V in CAPD by different estimations of V. Kidney Int 1995;48:563–569
Bradbury MG, Smye SW, Brocklebank JT. Assessment of the sensitivity of bioimpedance to volume changes in body water. Pediatr Nephrol 1995; 9:337–340
Wühl E, Fusch C, Schärer K, Mehls O, Schaefer F. Assessment of total body water in paediatric patients on dialysis. Nephrol Dial Transplant 1996;11:75–80
Enia G, Sicuso G, Alati G, Zocalli C. Subjective global assessment of nutrition in dialysis patients. Nephrol Dial Transplant 1993; 8:1094–1098
Young GA, Kopple JD, Lindholm B, Vonesh EF, De Vecchi A, Scalamogna A, Castelnova C, Oreopoulos DG, Anderson GH, Bergstrom J, DiChiro J, Gentile D, Nissenson A, Sakhrani L, Brownjohn AM, Nolph KD, Prowant BF, Algrim CE, Martis L, Serkes KD. Nutritional assessment of continuous peritoneal dialysis patients: An international study. Am J Kidney Dis 1991; 17:462–471
Must A, Dallai GE, Dietz WH. Reference data for obesity: 85th and 95th percentiles of body mass index for children and adolescents. Am J Dis Child 1991; 145:259–263
Schaefer F, Georgi M, Wühl E, Schärer K. Reference curves for body mass index and percentage fat mass in healthy German schoolchildren and adolescents. Int J Obes 1998; (in press)
Schaefer F, Georgi M, Zieger A, Schärer K. Usefulness of bioelectric impedance and skinfold measurements in predicting fat-free mass derived from total body potassium in children. Pediatr Res 1994; 35:617–624
Schaefer F, Mehls O. Endocrine, metabolic and growth disorders. In M.A. Holliday, T.M. Barratt, E.D. Avner, eds. “Paediatric Nephrology” Baltimore, MD: Williams & Wilkins, 1994; pp. 1241–1286
Robin J, Flynn MA, Nolph KD. Total body potassium — a guide to nutritional health in patients undergoing continuous ambulatory peritoneal dialysis. Am J Clin Nutr 1981; 34:94–98
Buchwald R, Peña JC. Evaluation of nutritional status in patients on continuous ambulatory peritoneal dialysis (CAPD). Perit Dial Int 1989;9:295–301
Kaysen GA, Schoenfeld PY. Albumin homeostasis in patients undergoing continuous ambulatory peritoneal dialysis. Kidney Int 1984;25:107–114
Blake PG, Flowerdew G, Blake RM, Oreopoulos DG. Serum albumin in patients on continuous ambulatory peritoneal dialysis — predictors and correlations with outcomes. J Am Soc Nephrol 1993; 3:1501–1507
Struijk DG, Krediet RT, Koomen GCM, Boeschoten EW, Arisz L. The effect of serum albumin at the start of continuous ambulatory peritoneal dialysis treatment on patient survival. Perit Dial Int 1994; 14:121–126
Kopple JD, Jones MR, Keshaviah PR, Bergström J, Lindsay RM, Moran J, Nolph KD, Teehan BP. A proposed glossary for dialysis kinetics. Am J Kidney Dis 1995; 26:963–981
Borah MF, Schoenfeld PY, Gotch FA, Sargent JA, Wolfson M, Humphreys MH. Nitrogen balance during intermittent dialysis therapy of uremia. Kidney Int 1978; 14:491–500
Harmon W, Spinozzi N, Meyer A, Grupe WE. Use of protein catabolic rate to monitor pediatric hemodialysis. Dial Transplant 1981;10:324–330
Schaefer F, Wolf S, Klaus G, Langenbeck D, Mehls O. Higher Kt/V urea associated with greater protein catabolic rate and dietary protein intake in children treated with CCPD compared to CAPD. Adv Periton Dial 1994; 10:310–314
Keshaviah PR, Nolph KD, Moore HL, Prowant B, Emerson PF, Meyer M, Twardowski ZJ, Khanna R, Ponferrada L, Collins A. Lean body mass estimation by creatinine kinetics. J Am Soc Nephrol 1994; 4:1475–1485
Teschan PE, Ginn HE, Bourne JR, Ward JW, Hamel B, Nunnally JC, Musso M, Vaughn WK. Quantitative indices of clinical uremia. Kidney Int 1979;15:676–697
Blake PG, Sombolos K, Abraham G, Weissgarten J, Pemberton R, Chu GL, Oreopoulos DG. Lack of correlation between urea kinetic indices and clinical outcomes in CAPD patients. Kidney Int 1991; 39:700–706
Teehan BP, Schleifer CR, Brown J. Urea kinetic modeling is an appropriate assessment of adequacy. Semin Dial 1992; 5:189–192
DeAlvaro F, Bajo MA, Alvarez-Ude F, Vigil A, Molina A, Coronel F, Seigas R. Adequacy of peritoneal dialysis: Does KT/V have the same predictive value as in HD? A multicentre study. Adv Periton Dial 1992; 8:93–97
Lameire NH, Vanholder R, Veyt D, Lambert M-C, Ringoir S. A longitudinal, five year survey of urea kinetic parameters in CAPD patients. Kidney Int 1992; 42:426–432
Teehan BP, Schleifer CR, Brown JM, Sigler MH, Raimondo J. Urea kinetic analysis and clinical outcome on CAPD. A five year longitudinal study. Adv Periton Dial 1990; 6:181–185
Genestier S, Hedelin G, Schaffer P, Faller B. Prognostic factors in CAPD patients: A retrospective study of a 10 year period. Nephrol Dial Transplant 1995; 10:1905–1911
Maiorca R, Brunori G, Zubani R, Cancarini GC, Manili L, Camerini C, Movilli E, Pola A, D’Avolio G, Gelatti U. Predictive value of dialysis adequacy and nutritional indices for mortality and morbidity in CAPD and HD patients. A longitudinal study. Nephrol Dial Transplant 1995; 10:2295–2305
Canada-USA (CANUSA) Peritoneal Dialysis Study Group. Adequacy of dialysis and nutrition in continuous peritoneal dialysis: Association with clinical outcomes. J Am Soc Nephrol 1996; 7:198–207
Brandes JC, Piering WF, Beres JA, Blumenthal SS, Fritsche C. Clinical outcome of continuous ambulatory peritoneal dialysis predicted by urea and creatinine kinetics. J Am Soc Nephrol 1992; 2:1430–1435
Arkouche W, Delawari E, My H. Quantification of the adequacy of peritoneal dialysis. Perit Dial Int 1993; 13: S215–S218
Bergström J, Lindholm B. Nutrition and adequacy of dialysis. How haemodialysis and CAPD compare? Kidney Int 1993; 43:43
Spiegel DM, Andersson M, Campbell U, Hall K, Kelly G, McClure E, Breyer JA. Serum albumin: A marker for morbidity in peritoneal dialysis patients. Am J Kidney Dis 1993; 21:26–30
Harty J, Boulton H, Curwell J, Uttley L, Venning M, Gokal R. The normalized protein catabolic rateis a flawed marker of nutrition in CAPD patients. Kidney Int 1995; 45:103–109
Stein A, Walls J. The correlation between Kt/V and protein catabolic rate — a self-fulfilling prophecy. Nephrol Dial Transplant 1994; 9:743–745
Lowrie EG. Thoughts about judging dialysis treatment: Mathematics and measurements, mirrors in the mind. Semin Nephrol 1996; 16:242–262
McCusker FX, Teehan BP, Thorpe KE, Keshaviah PR, Churchill DN. How much peritoneal dialysis is required for the maintenance of a good nutritional state? Canada-USA (CANUSA) Peritoneal Dialysis Study Group. Kidney Int 1996; 50:S56–S61
Schaefer F, Klaus G, Mehls O, Mid European Study Group for Pediatric CAPD/CCPD. Peritoneal membrane type and dose of dialysis affect growth and body composition in children on peritoneal dialysis. Pediatr Nephrol 1997; 11:C28
Pollock CA, Ibels LS, Allen BJ, Ayass W, Caterson RJ, Waugh DA, Macadam C, Pennock Y, Mahony JF. Total body nitrogen as a prognostic marker in maintenance dialysis. J Am Soc Nephrol 1995; 6:82–88
Fung L, Pollock CA, Caterson RJ, Mahony JF, Waugh DA Macadam C, Ibels LS. Dialysis adequacy and nutrition determine prognosis in continuous ambulatory peritoneal dialysis patients. J Am Soc Nephrol 1996; 7:745–750
Bergström J, Lindholm B. Nutrition and adequacy of dialysis. How do hemodialysis and CAPD compare? Kidney Int 1993; 43:S39-39S50
Williams P, Jones J, Marriott J. Do increases in dialysis dose lead to nutritional improvements? Nephrol Dial Transplant 1994; 9:1841–1842
Lindsay RM, Spanner E, Heidenheim RP, Lefebvre JM, Hodsman A, Baird J, Allison ME. Which comes first, Kt/V or PCR — Chicken or egg? Kidney Int 1993; 42:S160–S164
Burkart JM, Poole D, Rocco MV. Relation between Kt/V and dietary protein intake is calculated using nine day food record data. J Am Soc Nephrol 1994; 5:489
Blake PG, Sombolos K, Izatt S, Oreopoulos DG. Low serum albumin predicts poor outcome in CAPD and is related to high peritoneal permeability. J Am Soc Nephrol 1990; 1:383
Nolph KD, Moore HL, Prowant B, Twardowski ZJ, Khanna R, Gamboa S, Keshaviah P. Continuous ambulatory peritoneal dialysis with a high flux membrane. ASAIO J 1993; 39:904–909
Malhotra D, Tzamaloukas AH, Murata GH, Fox L, Goldman RS, Avasthi PS. Serum albumin in continuous peritoneal dialysis: its predictors and relationship to urea clearance. Kidney Int 1996; 50:243–249
Fried L. Higher membrane permeability predicts poorer patient survival. Perit Dial Int 1997; 17:387–388
Churchill DN, Thorpe KE, Nolph KD, Oreopoulos DG, Paget D, Keshaviah PR, for the Canada/USA Peritoneal Dialysis Study Group. CAPD patient and technique survivals are worse with increased membrane permeability. Perit Dial Int 1996; 16:S21
Kagan A, Bar-Khayim Y. Role of peritoneal loss of albumin in the hypoalbuminemia of continuous ambulatory peritoneal dialysis patients: relationship to peritoneal transport of solutes. Nephron 1995; 71:314–320
Harty JC, Boulton H, Venning MC, Gokal R. Is peritoneal permeability an adverse risk factor for malnutrition in CAPD patients? Miner Electrolyte Metab 1996; 22:97–101
Levin N, Eknoyan G, Pipp M, Steinberg E. National Kidney Foundation: Dialysis Outcome Quality Initiative — development of methodology for clinical practice. Nephrol Dial Transplant 1997; 12:2060–2063
Ikizler TA, Greene JH, Wingard RL, Parker RA, Hakim RM. Spontaneous dietary protein intake during progression of chronic renal failure. J Am Soc Nephrol 1995; 6:1386–1391
Tattersall J, Greenwood R, Farrington K. Urea kinetics and when to commence dialysis. Am J Nephrol 1995; 15:283–289
Mehrotra R, Saran R, Moore HL, Prowant BF, Khanna R, Twardowski ZJ, Nolph KD. Towards targets for initiation of chronic dialysis. Perit Dial Int 1997; 17:497–508
Peers E, Gokal R. Icodextrin: overview of clinical experience. Perit Dial Int 1997; 17:22–26
Vonesh EF, Keshaviah PR. Applications in kinetic modeling using PD ADEQUEST. Perit Dial Int 1997; 17:S119–S125
Gotch FA, Lipps BJ. PACK PD: A urea kinetic modeling computer program for peritoneal dialysis. Perit Dial Int 1997; 17: S126–S130
Verrina E, Amici G, Trivelli A, Perfumo F, Gusmano R. Clinical validation of PD Adequest software in children: A pilot study. Perit Dial Int 1997; 17 Suppl 1:S91
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Schaefer, F. (1998). Adequacy of Peritoneal Dialysis in Children. In: Fine, R.N., Alexander, S.R., Warady, B.A. (eds) CAPD/CCPD in Children. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4931-4_8
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DOI: https://doi.org/10.1007/978-1-4615-4931-4_8
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