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Long chain fatty acids as modulators of gene transcription in preadipose cells

  • Chapter
Lipid Binding Proteins within Molecular and Cellular Biochemistry

Part of the book series: Molecular and Cellular Biochemistry ((DMCB,volume 29))

Abstract

During the last years, it has been clearly established that long-chain fatty acids act as modulators of gene expression in various tissues, such as adipose tissue, intestine and liver. This transcriptional action of fatty acids explains in part adaptation mechanisms of tissues to nutritional changes and especially to high-fat diets by increasing expression of proteins involved in lipid catabolism in liver and fatty acid uptake and utilization in other tissues. It is now clearly demonstrated that some of these transcriptional effects of fatty acids are mediated by activation of specific nuclear hormone receptors, called peroxisome proliferator-activated receptors (PPARs). These findings will be discussed with a special reference to control of gene expression in preadipocytes and adipose tissue development. (Mol Cell Biochem 192: 63–68, 1999)

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Abbreviations

ACS:

acyl-CoA-synthetase

ALBP:

adipocyte lipid-binding protein

FABP:

fatty acid-binding protein

FAT:

fatty acid transporter

L-FABP:

liver-fatty acid-binding protein

GPDH:

glycerophosphate dehydrogenase

GAPDH:

glyceraldehyde-3 -P-dehydrogenase

LCFA:

long-chain fatty acid

PGJ2:

prostaglandin 12

PPAR:

peroxisome proliferatoractivated receptor

PPRE:

peroxisome proliferator-respon sive element

PUFA:

polyunsaturated fatty acid

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Authors and Affiliations

  1. INSERM U 470, Centre de Biochimie, UFR Sciences, Université de Nice-Sophia Antipolis, Parc Valrose, Nice, France

    Paul A. Grimaldi, Lydia Teboul, Danielle Gaillard, Anne V. Armengod & Ez Z. Amri

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  1. Paul A. Grimaldi
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  2. Lydia Teboul
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  3. Danielle Gaillard
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  4. Anne V. Armengod
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  5. Ez Z. Amri
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Editors and Affiliations

  1. Department of Biochemistry, University of Minnesota, Minneapolis, MN, USA

    Leonard Banaszak

  2. Department of Biochemistry, University of Minnesota, St Paul, MN, USA

    David A. Bernlohr

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© 1999 Springer Science+Business Media Dordrecht

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Grimaldi, P.A., Teboul, L., Gaillard, D., Armengod, A.V., Amri, E.Z. (1999). Long chain fatty acids as modulators of gene transcription in preadipose cells. In: Banaszak, L., Bernlohr, D.A. (eds) Lipid Binding Proteins within Molecular and Cellular Biochemistry. Molecular and Cellular Biochemistry, vol 29. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4929-1_7

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  • DOI: https://doi.org/10.1007/978-1-4615-4929-1_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7236-3

  • Online ISBN: 978-1-4615-4929-1

  • eBook Packages: Springer Book Archive

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