Abstract
The cellular theory of immunity was first proposed in 1884 by Ilya Metchnikoff, who also is well-known among insect pathologists for his studies on the fungus Metarhizium anisopliae (see Chapter 10). Basically, Metchnikoff proposed that the mechanisms for intracellular digestion which function in nutrition and self-defense in protozoans have survived in the amoeboid phagocytes of higher forms. In addition, he suggested that such phagocytic cells, which serve primarily in the uptake and digestion of nonself substances and cellular debris (e.g., damaged and senescent cells), constitute the first line of defense against invasion of potentially pathogenic organisms.
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Boucias, D.G., Pendland, J.C. (1998). Insect Immune Defense System, Part II: The Recognition of Nonself. In: Principles of Insect Pathology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4915-4_14
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DOI: https://doi.org/10.1007/978-1-4615-4915-4_14
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