The Investigation of Protein Dynamics Via the Spectral Density Function

  • R. Andrew Atkinson
  • Jean-François Lefèvre
Part of the NATO ASI Series book series (NSSA, volume 301)


Spectral density mapping provides direct access to information on protein dynamics, by the solution of the equations for heteronuclear relaxation rates, with no assumptions as to the nature of the molecule or its dynamic behaviour. Reduced spectral density mapping allows the detailed characterisation of a protein’s motions at a lower experimental burden than the full approach. Spectral density profiles may readily be interpreted to yield information on flexibility or slow conformational exchange and to describe the anisotropic nature of the molecule.


Spectral Density Principal Axis Relaxation Rate Correlation Time Internal Motion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • R. Andrew Atkinson
    • 1
  • Jean-François Lefèvre
    • 1
  1. 1.Ecole Supérieure de Biotechnologie de StrasbourgUPR 9003 du CNRSIllkirchFrance

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