Monitoring Protein Folding Using Time-Resolved Biophysical Techniques

  • Kevin W. Plaxco
  • Christopher M. Dobson
Part of the NATO ASI Series book series (NSSA, volume 301)


Many of the biophysical techniques developed to characterize native proteins at equilibrium have now been adapted to the structural and thermodynamic characterization of transient species populated during protein folding. Recent advances in these techniques, the use of novel methods of initiating refolding, and a convergence of theoretical and experimental approaches are leading to a detailed understanding of many aspects of the folding process.


Dynamic Nuclear Polarization Folding Process Chemically Induce Dynamic Nuclear Polarization Biophysical Technique Core Packing 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.





circular dichroism


chymotrypsin inhibitor 2


chemically induced dynamic nuclear polarization


infrared spectroscopy


mass spectrometry


nuclear Overhauser effect


nuclear magnetic resonance






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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Kevin W. Plaxco
    • 1
  • Christopher M. Dobson
    • 2
  1. 1.Department of BiochemistryUniversity of WashingtonSeattleUSA
  2. 2.Oxford Centre for Molecular Sciences New Chemistry LaboratoryUniversity of OxfordOxfordUK

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