Modeling Epileptic Disorders in Mice

  • Thomas N. Seyfried
  • Michael Poderycki
  • Mariana Todorova
Part of the Advances in Neurochemistry book series (ANCH, volume 9)


Epilepsy can be defined generally as intermittent neuronal dysfunction resulting from sudden, disorderly discharges of central nervous system (CNS) neurons. With the exception of cerebrovascular disease, epilepsy is the most prevalent human neurological disorder. Seizures are a symptom of epilepsy and can be either convulsive (with overt motor manifestations) or nonconvulsive (without motor involvement). The classification of epilepsy based on seizure phenotype is complex and often ambiguous. A plethora of epilepsy phenotypes may arise from seizures originating in cortical or subcortical brain regions. The seizures are often described as generalized, involving the cortex of both hemispheres, or as partial, involving a specific cortical region. Partial seizures can be further categorized as simple (without loss of consciousness) or complex (consciousness impaired). Seizure phenotypes can also be modified significantly by age (Delgado-Escueta et al., 1982). Because the seizure behavioral phenotype is removed from its biochemical or physiological cause, epilepsy classification based on seizure phenotype is controversial.


Vestibular Stimulation Audiogenic Seizure Seizure Susceptibility Spontaneous Seizure Idiopathic Epilepsy 
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Copyright information

© Kluwer Academic/Plenum Publishers 1999

Authors and Affiliations

  • Thomas N. Seyfried
    • 1
  • Michael Poderycki
    • 1
  • Mariana Todorova
    • 1
  1. 1.Department of BiologyBoston CollegeChestnut Hill

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