Multifocal Cortical Neurodegeneration in Alzheimer’s Disease

  • Brent A. Vogt
  • Alex Martin
  • Kent E. Vrana
  • John R. Absher
  • Leslie J. Vogt
  • Patrick R. Hof
Part of the Cerebral Cortex book series (CECO, volume 14)


Cortical atrophy is well known in Alzheimer’s disease (AD), however, there are different interpretations of its location and extent. Neurodegeneration and atrophy are relatively consistent in medial temporal areas, including hippocampal, entorhinal, and perirhinal cortices, and they follow a uniform pattern. This is not the only region of atrophy, however, since it occurs in prefrontal, parietotemporal, occipital, and cingulate cortices. Furthermore, although gross focal atrophy is not always present, focal neurodegeneration may occur with focal changes in glucose metabolism. The concept of multifocal cortical degeneration leads to the view of multiple structural and functional subsystem disruption in AD.


Posterior Cingulate Cortex Lewy Body Dementia Posterior Cortical Atrophy Amyloid Precursor Protein Mutation Laminar Pattern 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Brent A. Vogt
    • 1
    • 2
  • Alex Martin
    • 3
  • Kent E. Vrana
    • 1
    • 2
  • John R. Absher
    • 1
    • 2
  • Leslie J. Vogt
    • 1
    • 2
  • Patrick R. Hof
    • 4
  1. 1.Cingulum Neuro-Sciences InstituteWinston-SalemUSA
  2. 2.Departments of Physiology, Pharmacology, and NeurologyWake Forest University School of MedicineWinston-SalemUSA
  3. 3.National Institute of Mental HealthBethesdaUSA
  4. 4.Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology and Department of Geriatrics and Adult Development, and Department of OpthalmologyMount Sinai School of MedicineNew YorkUSA

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