Abstract
There is increasing evidence that an important aspect of gene expression in neurons involves local synthesis of proteins in their dendrites. Dendrites contain: (a) the relevant protein synthetic organelles—polyribosomes, rough endoplasmic reticulum (RER) and small elements of Golgi apparatus (1); (b) translational elements—rRNA, tRNA and translational factors (1,2); (c) certain mRNAs (1,3). Local synthesis of a variety of proteins has been demonstrated (4), as has the ability of dendrites to translate exogenously applied mRNAs (3).
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Ma, D., Morris, J.F. (1998). Local Protein Synthesis in Magnocellular Dendrites. In: Zingg, H.H., Bourque, C.W., Bichet, D.G. (eds) Vasopressin and Oxytocin. Advances in Experimental Medicine and Biology, vol 449. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4871-3_5
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DOI: https://doi.org/10.1007/978-1-4615-4871-3_5
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