Identification of a Constitutively Active Mutant of the Human Oxytocin Receptor

  • Bice Chini
  • Elena Albertazzi
  • Piero De Benedetti
  • Francesca Fanelli
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 449)

Abstract

Oxytocin (OT) and vasopressin (AVP) receptors belong to the G-protein-coupled receptor family; in these receptors, the peptide agonists bind to a region delimited by the upper third of the transmembrane part of the molecule (1) and the molecular interactions responsible for agonist selectivity have been extensively investigated (2–5). However, nothing is known on the intramolecular changes that characterize the active conformation(s) of these receptors. In order to get a better understanding of the process of receptor activation, we started a project aimed at the identification of the key residues involved in stabilizing the active conformation(s) of the human oxytocin receptor.

Keywords

Arginine Alanine Vasopressin Inositol Oxytocin 

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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Bice Chini
    • 1
  • Elena Albertazzi
    • 1
  • Piero De Benedetti
    • 2
  • Francesca Fanelli
    • 2
  1. 1.CNR Cellular and Molecular Pharmacology CenterMilanItaly
  2. 2.Department of ChemistryUniversity of ModenaModenaItaly

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