Structure/Function Studies on Receptors for Vasopressin and Oxytocin

  • M. Wheatley
  • S. R. Hawtin
  • N. J. Yarwood
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 449)


The neurohypophysial hormones oxytocin (OT) and vasopressin (AVP) mediate their physiological role through interaction with specific receptors. The cloning of OT receptors (OTRs) and AVP receptors (VPRs) from several species has revealed the existence of four receptor subtypes (OT, V1a, V1b and V2). Sequence analysis of these cloned receptors has confirmed that they belong to the G-protein-coupled receptor (GPCR) family, characterised by seven hydrophobic αÁ-helical transmembrane (TM) domains.


Glycosylation Site Extracellular Loop Vasopressin Receptor Antagonist Binding Putative Glycosylation Site 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • M. Wheatley
    • 1
  • S. R. Hawtin
    • 1
  • N. J. Yarwood
    • 1
  1. 1.School of BiochemistryThe University of BirminghamEdgbaston, BirminghamUK

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