Regulation of Vasopressin Release by Ionotropic Glutamate Receptor Agonists
Part of the
Advances in Experimental Medicine and Biology
book series (AEMB, volume 449)
Immunocytochemistry, in situ hybridization, and electrophysiological techniques have demonstrated the presence of excitatory amino acid (EAA) receptors in the supraoptic nuclei(1–4). A role for EAA regulation of vasopressin (VP) release is suggested by the ability of the non-specific EAA antagonist, kynureic acid, to inhibit osmotically stimulated VP release from explants of the hypothalamo-neurohypophyseal system (HNS)(5). In addition, both N-methyl-D-aspartate (NMDA) receptor antagonists (AP5 and MK801) and the non-NMDA receptor antagonist, DNQX, applied independently inhibit osmotically stimulated VP release implicating the importance of both classes of glutamate receptors in the regulation of VP release.
KeywordsGlutamate Receptor Excitatory Amino Acid Kainic Acid Kynureic Acid Receptor Desensitization
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