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The Role of The Neural Growth Associated Protein B-50/Gap-43 in Morphogenesis

  • Chapter
Molecular and Cellular Mechanisms of Neuronal Plasticity

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 446))

Abstract

Axonal guidance during development and regeneration can largely be attributed to a specialized structure at the distal end of a neurite called the growth cone (Ramon y Cajal, 1966). Structurally, these highly dynamic swellings can be divided into three distinct regions: a base, a central region and a peripheral region. The base is formed by the transition from growth cone to neurite, where bundles of microtubules diverge and extend into the central region. This region consists of a microtubular skeleton and is rich in membranous organelles such as mitochondria, dense and clear cored vesicles and endoplasmic reticu-lum like structures. The flattened leading edge of the growth cone, the peripheral region, is filled with a dense meshwork of actin filaments and is virtually devoid of microtubules and organelles. Growth cone and neurite architecture and motility are supported by a complex network of cell adhesion molecules, microtubules, actin, intermediate filaments and specific interacting regulatory proteins.

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Authors and Affiliations

  1. Rudolf Magnus Institute for Neurosciences, Laboratory of Physiological Chemistry, USA

    L. H. J. Aarts, P. Schotman & L. H. Schrama

  2. Department of Medical Pharmacology Stratenum, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands

    W. H. Gispen

  3. Netherlands Institute for Brain Research, Meibergdreef 33, 1105AZ, Amsterdam, The Netherlands

    J. Verhaagen

Authors
  1. L. H. J. Aarts
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  2. P. Schotman
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  3. J. Verhaagen
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  4. L. H. Schrama
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  5. W. H. Gispen
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Editors and Affiliations

  1. The College of Staten Island of The City University of New York, USA

    Yigal H. Ehrlich

  2. The CSI/IBR Center for Developmental Neuroscience Staten Island, New York, USA

    Yigal H. Ehrlich

  3. The City University Graduate School, New York, New York, USA

    Yigal H. Ehrlich

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Aarts, L.H.J., Schotman, P., Verhaagen, J., Schrama, L.H., Gispen, W.H. (1998). The Role of The Neural Growth Associated Protein B-50/Gap-43 in Morphogenesis. In: Ehrlich, Y.H. (eds) Molecular and Cellular Mechanisms of Neuronal Plasticity. Advances in Experimental Medicine and Biology, vol 446. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4869-0_6

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  • DOI: https://doi.org/10.1007/978-1-4615-4869-0_6

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