Alterations of Electron Transfer and Energy Conservation in Mitochondrial Complex I (Nadh-Coenzyme Q Oxido-Reductase) in Aging

  • Maria Luisa Genova
  • Milena Merlo Pich
  • Francesco Pallotti
  • Romana Fato
  • Gabriella Formiggini
  • Carla Bovina
  • Giovanna Parenti Castelli
  • Giorgio Lenaz


The aging process is characteristically associated with a progressive decline in physiological functions. This is likely related to a failure of mitochondrial energy production as a consequence of impairment of the mitochondria) oxidative phosphorylation system.


NADH Oxidase Aerobic Oxidation Electron Transport Activity NADH Oxidase Activity Mitochondrial Energy Production 
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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Maria Luisa Genova
    • 1
  • Milena Merlo Pich
    • 1
  • Francesco Pallotti
    • 2
  • Romana Fato
    • 1
  • Gabriella Formiggini
    • 1
  • Carla Bovina
    • 1
  • Giovanna Parenti Castelli
    • 1
  • Giorgio Lenaz
    • 1
  1. 1.Dipartimento di BiochimicaUniversità di BolognaBolognaItaly
  2. 2.Istituto di IstologiaUniversità di BolognaBolognaItaly

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