Health Aspects of Mobile Communication: Risks to the Central Nervous System

  • Konstantin-Alexander Hossmann
  • Dirk Matthias Hermann


The wide and growing use of mobile communication has raised concerns about adverse interactions of electromagnetic radiation with the human organism and, in particular, the brain. Due to the close proximity of the mobile telephone device to the head, the brain is exposed to relatively high specific absorption rates (SAR), compared with the rest of the body. Numerical measurements during normal operation of GSM communication devices in the 900 MHz range have shown that, averaged over any 10 g of tissue, a maximum spatial SAR of 0.525 W/kg is reached in the brain1, and that the peak SAR may increase up to 0.75W/kg for devices operating in the 1.8 GHZ range2. These values are not too far away from the 1–4W/kg threshold at which body temperature begins to rise3, and there is ample evidence of biological effects due to heat stress. It is, therefore, conceiveable that some of the here reported effects are, in fact, due to spurious temperature changes.


Microwave Radiation Mobile Communication Specific Absorption Rate Microwave Exposure Microwave Effect 
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  1. 1.
    ICNIRP, Health issues related to the use of hand-held radiotelephones and base transmitters, Health Physics 70:587–593 (1996).Google Scholar
  2. 2.
    Dimbylow, P.J. and Mann, S.M., SAR calculation in an anatomically realistic model of the head for mobile communication transceivers at 900 MHz and 1.8 GHz, Physics in Medicine and Biology 39:1537–1553 (1994).ADSCrossRefGoogle Scholar
  3. 3.
    IEEE, IEEE Standard for safety levels with respect to human exposure to radiofrequency electromagnetic fields, 3 kHz to 300 GHz. New York; Institute of Electrical and Electronic Engineers: C95.1, (1991).Google Scholar
  4. 4.
    McKinlay, A., Possible health effects related to the use of radiotelephones, Radiol. Protect. Bull 187:9–16 (1997).Google Scholar
  5. 5.
    Hermann, D.M. and Hossmann, K.-A., Neurological effects of microwave exposure related to mobile communication, J. Neural. Sci. 152:1–14 (1997).ADSCrossRefGoogle Scholar
  6. 6.
    Wachtel, H., Seaman, R. and Joines, W., Effects of low-intensity microwaves on isolated neurons, Ann. NY Acad. Sci. 247:46–62 (1975).ADSCrossRefGoogle Scholar
  7. 7.
    Seaman, R.L. and Wachtel, H., Slow and rapid responses to CW and pulsed microwave radiation by individual Aplysia pacemakers, Journal of Microwave Power 13:77–86 (1978).Google Scholar
  8. 8.
    Arber, S.L. and Lin, J.C., Microwave-induced changes in nerve cells: effects of modulation and temperature, Bioelectromagnetics 6:257–270 (1985).CrossRefGoogle Scholar
  9. 9.
    McRee, D.I. and Wachtel, H., The effects of microwave radiation on the vitality of isolated frog sciatic nerves, Radiat. Res. 82:536–546 (1980).CrossRefGoogle Scholar
  10. 10.
    Wang, Z., Van Dorp, R., Weidema, A.F. and Ypey, D.L., No evidence for effects of mild microwave irradiation on electrophysiological and morphological properties of cultured embryonic rat dorsal root ganglion cells, European Journal of Morphology 29:198–206 (1991).Google Scholar
  11. 11.
    Blackman, C.F., Benane, S.G., Elder, J.A., House, D.E., Lampe, J.A. and Faulk, J.M., Induction of calcium ion efflux from brain tissue by radiofrequence radiation: effect of sample number and modulation frequency on the power-density window, Bioelectromagnetics 12:173–182 (1980).CrossRefGoogle Scholar
  12. 12.
    Bawin, S.M., Kaczmarek, L.K. and Adey, W.R., Effects of modulated VHF fields on the central nervous system, Ann. NY Acad. Sci. 247:74–81 (1975).ADSCrossRefGoogle Scholar
  13. 13.
    Sheppard, A.R., Bawin, S.M. and Adey, W.R., Models of long-range order in cerebral macromolecules: effect of sub-ELF and of modulated VHF and UHF fields, Radio Sci. 14:141–145 (1979).ADSCrossRefGoogle Scholar
  14. 14.
    Shelton, W.W. and Merritt, J.H., In vitro study of microwave effects on calcium efflux in rat brain tissue, Bioelectromagnetics 2:161–167 (1981).CrossRefGoogle Scholar
  15. 15.
    Merritt, J.H., Shelton, W.W. and Chamness, A.F., Attempts to alter 45Ca2+ binding to brain tissue with pulse-modulated microwave energy, Bioelectromagnetics 3:475–478 (1982).CrossRefGoogle Scholar
  16. 16.
    Gandhi, C.R. and Ross, D.H., Microwave induced stimulation of32 Pi-incorporation into phsophoinositides of rat brain synaptosomes, Radial. Environ. Biophys. 28:223–234 (1989).CrossRefGoogle Scholar
  17. 17.
    Shandala, M.G., Dumanski, U.D., Rudnev, M.I., Ershova, L.K. and Los, I.P., Study of nonionizing microwave radiation effects upon the central nervous system and behavior reaction, Environmental Health Perspectives 30:115–121 (1979).Google Scholar
  18. 18.
    Thuroczy, G., Kubinyi, G., Bodo, M., Balms, J. and Szabo, L.D., Simultaneous response of brain electrical activity (EEG) and cerebral circulation (REG) to microwave exposure in rats, Review of Environmental Health 10:135–148 (1994).Google Scholar
  19. 19.
    McGinty, D. and Szymusiak, R., Keeping cool: a hypothesis about the mechanisms and functions of slow-wave sleep, Trends Neurosci. 13:480–487 (1990).CrossRefGoogle Scholar
  20. 20.
    Chou, C.K., Yee, K.C. and Guy, A.W., Auditory response in rats exposed to 2450 MHz electromagnetic fields in a circularly polarized waveguide, Bioelectromagnetics 6:323–326 (1985).CrossRefGoogle Scholar
  21. 21.
    Chou, C.K., Guy, A.W. and Galambos, R., Auditory perception of radiofrequency electromagnetic fields, J. Acoust. Soc. Am. 71:1321–1334 (1982).ADSCrossRefGoogle Scholar
  22. 22.
    Seaman, R.L. and Lebowitz, R.M., Thresholds of cat cochlear nucleus neurons to microwave pulses, Bioelectromagnetics 10:147–160 (1989).CrossRefGoogle Scholar
  23. 23.
    Inaba, R., Shishido, K., Okada, A. and Moroji, T., Effects of whole body microwave exposure on the rat brain contents of biogenic amines, European Journal of Applied Physiology 65:124–128 (1992).CrossRefGoogle Scholar
  24. 24.
    Merritt, J.H., Chamnes, A.F., Hartzell, R.H. and Allan, S.J., Orientation effect on microwave-induced hyperthermia and neurochemical correlates, Journal of Microwave Power 12:167–172 (1977).Google Scholar
  25. 25.
    Grin, A.N., Effects of microwave on catecholamine metabolism inbrain, US Joint Pub. Research Device Rep JPRS 72606. (1974).Google Scholar
  26. 26.
    Modak, A.T., Stavinoha, W.B. and Dean, U.P., Effect of short electromagnetic pulses on brain acetylcholine content and spontaneous motor activity in mice, Bioelectromagnetics 2:89–92 (1981).CrossRefGoogle Scholar
  27. 27.
    Baranski, S., Arber, S.L. and Lin, J.C., Histological and histochemical effects of microwave irradiation on the central nervous system of rabbits and guinea pigs, American Journal of Physiological Medicine 51:182–190 (1972).Google Scholar
  28. 28.
    Galvin, M.I., Parks, D.L. and McRee, D.L., Influence of 2.45 GHz microwave radiation on enzyme activity, Radial’. Environ. Biophys. 19:149–156 (1981).CrossRefGoogle Scholar
  29. 29.
    Millar, D.B., Christopher, J.P., Hunter, J. and Yeandle, S.S., The effect of exposure of acetylcholinesterase to 2450 MHz microwave radiation, Bioelectromagnetics 5:165–172 (1984).CrossRefGoogle Scholar
  30. 30.
    Lai, H., Carino, M.A., Wen, Y.F., Morita, A. and Guy, A.W., Naltrexone pretreatment blocks microwave-induced changes in central cholinergic receptors, Bioelectromagnetics 12:27–33 (1991).CrossRefGoogle Scholar
  31. 31.
    Lai, H., Carino, M.A. and Guy, A.W., Low-level microwave irradiation and central cholinergic systems, Pharmacology Biochemistry and Behavior 33:131–138 (1989).CrossRefGoogle Scholar
  32. 32.
    Sanders, A.P., Schaefer, D.J. and Joines, W.T., Microwave effects on energy metabolism of rat brain, Bioelectromagnetics 1:171–182 (1980).CrossRefGoogle Scholar
  33. 33.
    Sanders, A.P. and Joines, W.T., The effects of hyperthermia and hyperthermia plus microwaves on rat brain energy metabolism, Bioelectromagnetics 5:63–70 (1984).CrossRefGoogle Scholar
  34. 34.
    Sanders, A.P., Joines, W.T. and Allis, J.W., Effect of continuous-wave, pulsed, and sinusoidal-amplitude-modulated microwaves on brain energy metabolism, Bioelectromagnetics 6:89–97 (1985).CrossRefGoogle Scholar
  35. 35.
    Lai, H. and Singh, N.P., Single-and double-strand DNA breaks in rat brain cells after acute exposure to radiofrequency electromagnetic radiation, Int. J. Radial. Biol. 69:513–521 (1996).CrossRefGoogle Scholar
  36. 36.
    Fritze, K., Wiessner, C., Kuster, N., Sommer, C., Gass, P., Hermann, D.M., Kiessling, M. and Hossmann, K.-A., Effect of GSM microwave exposure on the genomic response of the rat brain, Neuroscience 81:627–639 (1997).CrossRefGoogle Scholar
  37. 37.
    Albert, E.N. and Kerns, J.M., Reversible microwave effects on the blood-brain barrier, Brain Res. 230:153–164 (1981).CrossRefGoogle Scholar
  38. 38.
    Fritze, K., Sommer, C., Schmitz, B., Mies, G., Hossmann, K.-A., Kiessling, M. and Wiessner, C., Effect of GSM microwave exposure on blood-brain barrier, Acta Neuropathologica 94:465–470 (1997).CrossRefGoogle Scholar
  39. 39.
    Neubauer, C., Phelan, A.M., Kues, H. and Lange, D.G., Microwave irradiation of rats at 2.45 GHz activates pinocytic-like uptake of tracer by capillary endothelial cells of cerebral cortex, Bioelectromagnetics 11:261–268 (1990).CrossRefGoogle Scholar
  40. 40.
    Salford, L.S., Brun, A., Sturesson, K., Eberhardt, J.L. and Persson, B.R.R., Permeability of the blood-brain barrier induced by 915 MHz electromagnetic radiation, continuous wave and modulated at 8, 50, and 200 Hz, Microscopy Research and Technique 27:535–542 (1994).CrossRefGoogle Scholar
  41. 41.
    Preston, E., Vavasour, E.J. and Assenheim, H.M., Permeability of the blood-brain barrier to mannitol in the rat following 2,450 MHz microwave irradiation, Brain Res. 174:109–117 (1979).CrossRefGoogle Scholar
  42. 42.
    Gruenau, S.P., Oscar, K.J., Folker, M.T. and Rapoport, S.I., Absence of microwave effect on blood-brain barrier permeability to 14C-sucrose in the conscious rat, Exp. Neurol. 75:299–307 (1982).CrossRefGoogle Scholar
  43. 43.
    Ward, T.R., Elder, I.A., Long, M.D. and Svendsgaard, D., Measurement of blood-brain barrier permeation in rats during exposure to 2450-MHz microwaves, Bioelectromagnetics 3:371–383 (1982).CrossRefGoogle Scholar
  44. 44.
    Garber, J.H., Oldendorf, W.H., Braun, L.D. and Lufkin, R.B., MRI gradient fields increase brain mannitol space, Magn. Reson. Imaging 7:605–610 (1989).CrossRefGoogle Scholar
  45. 45.
    Prato, F.S., Frappier, J.R.H., Shivers, R.R., Kavaliers, M., Zabel, P., Drost, D.J. and Lee, T.-Y., Magnetic resonance imaging increases the blood-brain barrier permeability to 153-gadolinium diethylenetriaminepentaacetic acid in rats, Brain Res. 523:301–304 (1990).CrossRefGoogle Scholar
  46. 46.
    Shivers, R.R., Kavaliers, M., Teskey, G.C., Prato, F.S. and Pelletier, R.M., Magnetic resonance imaging temporarily alters blood-brain barrier permeability in the rat, Neurosci. Lett. 76:25–31 (1987).CrossRefGoogle Scholar
  47. 47.
    Liburdy, R.P., DeManincor, D.J., Roos, M.S. and Brennan, K.M., Permeability of the blood-brain barrier of the rat is not significantly altered by NMR exposure, Ann. NY Acad. Sci. 649:345–349 (1992).ADSCrossRefGoogle Scholar
  48. 48.
    Persson, B.R.R., Salford, L.G., Brun, A., Eberhardt, J.L. and Malmgren, L., Increased permeability of the blood-brain barrier induced by magnetic and electromagnetic fields, Ann. NY Acad. Sci. 649:356–358 (1992).ADSCrossRefGoogle Scholar
  49. 49.
    Merritt, J.H., Chamness, A.P. and Allen, S.J., Studies on blood-brain barrier permeability after microwave radiation, Radial. Environ. Biophvs. 15:367–377 (1978).CrossRefGoogle Scholar
  50. 50.
    Chang, B.K., Huang, A.T., Joines, W.T. and Kramer, R.S., The effect of microwave radiation (1.0 GHz) on the blood-brain barrier, Radio Sci. 17:165–168 (1982).ADSCrossRefGoogle Scholar
  51. 51.
    Oscar, K.J. and Hawkins, T.D., Microwave alteration of the blood-brain barrier system of rats, Brain Res. 126:281–293 (1977).CrossRefGoogle Scholar
  52. 52.
    von Klitzing, I., Low-Frequency pulsed electromagnetic fields influence EEG of man, Physica Medica 11:77–80 (1995).Google Scholar
  53. 53.
    Reiser, H.-P., Dimpfel, W. and Schober, F., The influence of electromagnetic fields on human brain activity, European Journal of Medical Research 1:27–32 (1995).Google Scholar
  54. 54.
    Mann, K. and Röschke, J., Effects of pulsed high-frequency electromagnetic fields on human sleep, Neuropsvchobiology 33:41–47 (1996).CrossRefGoogle Scholar
  55. 55.
    Pasche, B., Erman, M., Hayduk, R., Mitler, M.M., Reite, M., Higgs, L., Kuster, N., Rossel, C., Dafni, U., Amato, D., Barbault, A. and Lebet, J.-P., Effects of low energy emission therapy in chronic psychophysiological insomnia, Sleep 19:327–336 (1996).Google Scholar
  56. 56.
    Reite, M., Higgs, L., Lebet, J.-P., Barbault, A., Rossel, C., Kuster, N., Dafni, U., Amato, D. and Amato, B. P., Sleep inducing effect of low energy emission therapy, Bioelectromagnetics 15:67–75 (1994).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Konstantin-Alexander Hossmann
    • 1
  • Dirk Matthias Hermann
    • 1
  1. 1.Department of Experimental NeurologyMax-Planck-Institute for Neurological ResearchCologneGermany

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