Mechanistic Studies of Radiation-Induced DNA Damage

  • Clemens von Sonntag
Chapter
Part of the NATO ASI Series book series (NSSA, volume 302)

Abstract

In cells, the damage caused by ionizing radiation is mainly due to free-radical-induced alterations of their DNA. The reactions involved have been studied on a model level: DNA and DNA components in aqueous solution. OH radicals and solvated electrons yield short-lived intermediates such as nucleobase-OH-adduct radicals, radicals at the sugar moiety (and consequently strand breaks) and base radical anions. Their properties and reaction kinetics have been studied by pulse radiolysis and product analysis. Some aspects of the effect of O2 in potentially enhancing the damage and the protective effects of thiols and bisbenzimidazole derivatives are reported.

Keywords

Sugar Glutathione Adduct Tryptophan Thiol 

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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Clemens von Sonntag
    • 1
  1. 1.Max-Planck-Institut für StrahlenchemieMülheim/RuhrGermany

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