Peep Decreases Oxygenation of the Intestinal Mucosa Despite Normalization of Cardiac Output

  • A. Fournell
  • T. W. L. Scheeren
  • L. A. Schwarte
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 454)


To evaluate if normalization of cardiac output reverses the attenuation of local intracapillary hemoglobin saturation (HbO2) of gastric mucosa by PEEP (positive end-expiratory pressure) during IPPV (intermittent positive pressure ventilation).


Gastric Mucosa Multiple Organ Failure Hydroxyethyl Starch Intermittent Positive Pressure Ventilation Acute Respiratory Fail Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Barie PS. Organ-specific support in multiple organ failure: pulmonary support. World J Surg1995; 19(4): 581–91.PubMedCrossRefGoogle Scholar
  2. 2.
    Carrico CJ, Meakins JL, Marshall JC, Fry D, Maier RV. Multiple organ failure syndrome. The gastrointestinal tract: the “motor” of MOF. Arch Surg 1986; 121(2): 196–208.PubMedCrossRefGoogle Scholar
  3. 3.
    Fournell A, Scheeren TWL, Schwarte LA. Oxygenation of the intestinal mucosa in anaesthetized dogs is attenuated by intermittent positive pressure ventilation (IPPV) with positive end-expiratory pressure (PEEP). Adv Exp Med Biol; in press.Google Scholar
  4. 4.
    Frank KH, Kessler M, Appelbaum K, Dummler W. The Erlangen micro-lightguide spectro-photometer EMPHO I. Phys Med Biol 1989; 34(12): 1883–900.PubMedCrossRefGoogle Scholar
  5. 5.
    Berglund JE, Halden E, Jakobson S, Landelius J. Echocardiographic analysis of cardiac function during high PEEP ventilation. Intensive Care Med 1994; 20(3): 174–80.PubMedCrossRefGoogle Scholar
  6. 6.
    Dambrosio M, Fiore G, Brienza N, Cinnella G, Marucci M, Ranieri VM, Greco M, Brienza A. Right ventricular myocardial function in ARF patients. PEEP as a challenge for the right heart. Intensive Care Med 1996; 22(8): 772–80.PubMedCrossRefGoogle Scholar
  7. 7.
    Dantzker DR. The gastrointestinal tract. The canary of the body? JAMA 1993; 270(10): 1247–8.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • A. Fournell
    • 1
  • T. W. L. Scheeren
    • 2
  • L. A. Schwarte
    • 2
  1. 1.Department of Clinical AnesthesiologyHeinrich-Heine-UniversityDuesseldorfGermany
  2. 2.Department of Experimental AnesthesiologyHeinrich-Heine-UniversityDuesseldorfGermany

Personalised recommendations