Skip to main content

Increase of Neuronal Nitric Oxide Synthase during Chronic Hypoxia

  • Chapter
Book cover Oxygen Transport to Tissue XX

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 454))

Abstract

Nitric oxide (NO) is a remarkable biological messenger that participates in a wide range of functions in the central and peripheral nervous systems. Since this free-radical gas cannot be stored in synaptic vesicles like other neurotransmitters, the activity of nitric oxide synthase must be carefully modulated to provide appropriate levels of NO.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Bibliography

  1. Leone A.M., Palmer R. M.J., Knowles R.G., Francis P.L. Ashton D.S. and Moncada S. Constitutive and inducible nitric oxide synthases incorporate molecular oxygen into both nitric oxide and citrulline. J Biol Chem. 266(35):23790–23795, 1991.

    CAS  PubMed  Google Scholar 

  2. Abu-Soud H.M., Rousseau D.L and Stuehr D.J. Nitric oxide binding to the heme of neuronal nitric oxide synthase links its activity to changes in oxygen tension. J.Biol.Chem.271(51):32515–32518, 1996

    Article  CAS  PubMed  Google Scholar 

  3. Liao J.K., Zulueta J.J. Yu F. Peng H. Cote C.G. and Hassoun P.M. Regulation of bovine endothelial constitutive nitric oxide synthase by oxygen. J. Clin Invest. 96: 2661–266, Dec 1995.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  4. Arnet U.A., McMillant A., Dinerman J.L., Ballermann B. and Lowenstein C.J. Regulation of endothelial nitric oxide synthase during hypoxia.J. Biol. Chem. 271(25): 15069–15073, 1996.

    Article  CAS  PubMed  Google Scholar 

  5. Phelan M.W. and Faller D.V. Hypoxia decrease constitutive nitric oxide synthase transcript and protein in cultures endothelial cells. J. Cell Physiol. 167: 469–476, 1996.

    Article  CAS  PubMed  Google Scholar 

  6. Prabhakar N.R., Pieramici S.F., Premkumar D.R.D., Kumar G.K. and Kalaria R.N. Activation of nitric oxide synthase gene expression by hypoxia in central and peripheral neurons. Molecular Brain Research 43: 341–346, 1996.

    Article  CAS  PubMed  Google Scholar 

  7. Zhang ZG., Chopp M., Gautam S., Zaloga C., Lan Zhang R., Schmidt H., Pollock J.S. and Forstermann U. Upregulation of neuronal nitric oxide synthase and mRNA and selective sparing of nitric oxide synthase-containing neurons after focal cerebral ischemia in rat. Brain Research 654: 85–95, 1994.

    Article  CAS  PubMed  Google Scholar 

  8. Shaul, P.W., North A.J., Brannan T.S., Ujcic K., Wells L.W., Nisen P.A. Lowestein C.J. Snyder S.H. and Star R.A. Prolonge in vivo hypoxia enhances nitric oxide synthase Type I and Type III gene expression in adult rat lung. Am J. Reps. Celll Mol. Biol., 13: 167–174,1995.

    Article  CAS  Google Scholar 

  9. Le Cras T.D., Xue C, Rengasamy A. and Johns R.A. Chronic hypoxia upregulates endothelial and inducible NO synthase gene and protein expression in rat lung., Am. J. Physiol. 270: L164–L170, 1996.

    PubMed  Google Scholar 

  10. Dinerman J.L., Dawson T.M., Schell M.J., Snowman A., and Snyder S.H. Endothelial nitric oxide synthase localized to hippocampal pyramidal cells: Implications for synaptic plasticity. Proc Natl. Acad. Sci. USA. Vol.91, pp. 4214–4218, May 1994.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  11. Monge C. and Leon-Velarde F. Physiological Adaptation to High Altitude:Oxygen transport in Mammals and Birds. Physiological Rev. 71:1135–1171,1991.

    CAS  Google Scholar 

  12. LaManna J.C., Vendel L.M and Farrell R.M. Brain adaptation to chronic hypobaric hypoxia in rats.J.Appl.Physiol.72(6):2238–2243,1992.

    CAS  PubMed  Google Scholar 

  13. Mironov V, Hritz M.A., LaManna J.C., Hudetz A.G. and Harik S.I. Architectural alterations in rat cerebral microvessels after hypobaric hypoxia.Brain Res.660:73–80.1994.

    Article  CAS  PubMed  Google Scholar 

  14. Pipili-Synetos E., Sakkoula E. and Maragoudakis M.E.Nitric oxide is involved in the regulation of angiogenesis. Br. J. Pharmacol. 108(4):855–8857,1993.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  15. Morbidelli L., Chang C., Douglas J.G., Grander H.J., Ledda F. and Ziche M. Nitric Oxide mediates mitogenic effect of VEGF on coronary venulae endothelium. Am.J.Physiol, 270:H411–H415,1996.

    CAS  PubMed  Google Scholar 

  16. LaManna J.C., Boehm K.D., Mironov V, Hudentz A.G., Hritz M.A., Yun J.K. and Harik S.I. Increased basic fibroblastic growth factor mRNA in the brains of rats exposed to hypobaric hypoxia.In: “Oxygen Transport to Tissue XVI”, Hogan M.C., Mathieu-Costello O., Poole D.C., and Wagner P.D., eds, Plenum Publishing Corp. New York, pp. 497–502 (1994).

    Google Scholar 

  17. Kuo N-T., Benhayon D., Przybylski R.J., Martin R.J. and LaManna J.C.Time course of the hypobaric hypoxia induced vascular endothelial growth factor(VEGF)mRNA and protein in adult mouse brain.FASEB J 11:A292, 1997.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer Science+Business Media New York

About this chapter

Cite this chapter

Pichiule, P., Chavez, J.C., Przybylski, R.J., LaManna, J.C. (1998). Increase of Neuronal Nitric Oxide Synthase during Chronic Hypoxia. In: Hudetz, A.G., Bruley, D.F. (eds) Oxygen Transport to Tissue XX. Advances in Experimental Medicine and Biology, vol 454. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4863-8_37

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-4863-8_37

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7206-6

  • Online ISBN: 978-1-4615-4863-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics