Abstract
Multiple organ failure following severe hemorrhagic shock and trauma continues to be a major problem and accounts for a high mortality rate in surgical intensive care units. Persisting depression of micro vascular blood flow and, thus, tissue hypoxia have been suggested to promote multiple organ failure after hemorrhagic shock. Through modulation of the host response to shock and trauma the liver plays a central role for the maintenance of metabolic homeostasis, protein synthesis, as well as clearance and elimination of bacteria and endotoxins.
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Vollmar, B., Burkhardt, M., Minor, T., Klauke, H., Menger, M.D. (1998). A Correlation of Intravital Microscopically Assessed NADH Fluorescence, Tissue Oxygenation, and Organ Function during Shock and Resuscitation of the Rat Liver. In: Hudetz, A.G., Bruley, D.F. (eds) Oxygen Transport to Tissue XX. Advances in Experimental Medicine and Biology, vol 454. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4863-8_12
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DOI: https://doi.org/10.1007/978-1-4615-4863-8_12
Publisher Name: Springer, Boston, MA
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