Abstract
The lack of aerobic metabolism during ischemic organ preservation plays a pivotal role in the development of tissue alterations during the storage period and favours the manifestation of reper-fusion injuries, deteriorating organ viability upon postischemic resumption of nutritive blood circu-lation. Gaseous insufflation of oxygen via the venous vascular system has proven to be a useful tool to prevent anoxic tissue injury during extended time periods of ischemic preservation of kidneys (Isselhard et al., 1972) or livers (Minor and Isselhard, 1996; Minor et al., 1996) and to allow for an improved recovery of the persufflated organ after transplantation (Fischer et al., 1978; Minor et al., 1997b; Rolles et al., 1989).
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References
Fischer, J. H., Czerniak, A., Hauer, U., Isselhard, W., 1978, Anew simple method for optimal storage of ischemically damaged kidneys, Transplantation 25:43–49
Isselhard, W., Berger, M., Denecke, H., Witte, J., Fischer, J. H., Molzberger, H., 1972, Metabolism of canine kidneys in anaerobic ischemia and in aerobic ischemia by persufflation with gaseous oxygen, Pflügers Arch. 337:87–106
Minor, T., Isselhard, W., 1994, Venous oxygen insufflation to prevent reoxygenation injury after ischemia of a solid organ, Transplantation 58:121–123
Minor, T., Isselhard, W., 1996, Synthesis of high energy phosphates during cold ischemic rat liver preservation with gaseous oxygen insufflation, Transplantation 61:20–22
Minor, T., Klauke, H., Isselhard, W., 1996, Resuscitation of cadaveric livers from non heart-beating donors after warm ischemic insult. A novel technique tested in the rat, Experientia 52:661–663
Minor, T., Klauke, H., Isselhard, W., 1997a, Improved preservation of the small bowel by luminal gas-oxygenation, Transplant. Proc. in press
Minor, T., Klauke, H., Nagelschmidt, M., Isselhard, W., 1997b, Reduction of proteolysis by venous-systemic oxygen persufflation during rat liver preservation and improved functional outcome after transplantation, Transplantation 63:365–368
Rolles, K., Foreman, J., Pegg, D., 1989, A pilot clinical study of retrograde oxygen persufflation in renal preservation, Transplantation 48:339–342
Suematsu, M., Suzuki, H., Ishii, H., Tsuchiya, M., 1993, Paradox of oxygen-radical-dependent cell injury in the hypoxic liver microcirculation, Prog. Appl. Microcirc. 19:127–138
Vollmar, B., Burkardt, M., Minor, T., Klauke, H., Menger, M.D., 1997, In vivo microscopic determination of NADH fluorescence of livers for the monitoring of tissue oxygenation during hemorrhagic shock and resuscitation, Microvasc. Res. (in press)
Vollmar, B., Klauke, H., Minor, T., Isselhard, W., Menger, M.D., 1997, Gaseous pathway in venous oxygen persufflation of the liver, J. Hepatol. 26:1429–1430
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Minor, T., Vollmar, B., Klauke, H., Isselhard, W., Menger, M.D. (1998). Gaseous Oxygenation of the Ischemic Rat Liver. In: Hudetz, A.G., Bruley, D.F. (eds) Oxygen Transport to Tissue XX. Advances in Experimental Medicine and Biology, vol 454. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4863-8_11
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DOI: https://doi.org/10.1007/978-1-4615-4863-8_11
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