Cysteinyl-Leukotrienes and the Human Lung

  • Isabelle Gorenne
  • Carlos Labat
  • Xavier Norel
  • Jean-Pierre Gascard
  • Charles Brink
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 447)


Asthma is a chronic inflammatory disease of the airways involving recurrent airway obstruction. While the exact cause of this inflammation is presently unknown, allergen and locally released endogenous mediators play a crucial role in the severity and exacerbation of the symptoms associated with the disease.


Asthmatic Patient Human Airway Lung Sample Airway Muscle CysLT2 Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Schild, H.O., Hawkins, D.F., Mongar, J.L., and Herxheimer, H. (1951) Lancet 261, 376–382.CrossRefGoogle Scholar
  2. 2.
    Brocklehurst, W.E. (1960) J. Physiol. 151, 416–435.PubMedGoogle Scholar
  3. 3.
    Dahlen, S-E., Hansson, G., Hedqvist, P., Bjorck, T., Granstrom, E. and Dahlen, B. (1983) Proc. Natl. Acad. Sci. USA. 80, 1712–1716.PubMedCrossRefGoogle Scholar
  4. 4.
    Orange, R.P., Murphy, R.C., Karnovsky, M.L. and Austen, K.F. (1973) J. Immunol. 110, 760–770.PubMedGoogle Scholar
  5. 5.
    Undem, B.J., Pickett, W.C., Lichtenstein, L.M., and Adams, G.K. (1987) Am. Rev. Respir. Dis. 138, 1183–1187.Google Scholar
  6. 6.
    Murphy, R.C., Hammarstrom, S., and Samuelsson, B. (1979) Proc. Natl. Acad. Sci. USA. 764275–4279.PubMedCrossRefGoogle Scholar
  7. 7.
    Lam, S., Chan, H. Leriche, J.C., Chanyeung, M., and Salari, H. (1988) J. Allergy Clin. Immunol. 81, 711–717.PubMedCrossRefGoogle Scholar
  8. 8.
    Taylor, G.W., Taylor, I., Black, P., Maltby, N.H., Turner, N., Fuller, R.W., and Dollery, C.T. (1989) Lancet 1, 584–588.PubMedCrossRefGoogle Scholar
  9. 9.
    Coles, S.J., Neill, K.H., Reid, L.M., Austen, K.F., Nii, Y., Corey, E.J., and Lewis, R.A. (1983) Prostaglandins 25, 155–170.PubMedCrossRefGoogle Scholar
  10. 10.
    Dahlen, S-E., Bjorck, J., Hedqvist, P., Arfors, K.E., Hammarstrom, S., Lindgren, J.A., and Samuelsson, B. (1981) Proc. Natl. Acad. Sci. USA 78, 3887–3891.PubMedCrossRefGoogle Scholar
  11. 11.
    Dahlen, S-E., Hedqvist, P., Hammarstrom, S., and Samuelsson, B. (1980) Nature (London). 288, 484–486.PubMedCrossRefGoogle Scholar
  12. 12.
    Buckner, C.K., Krell, R.D., Lavaruso, R.B., Coursin, D.B., Bernstein, P.R., and Will, J.A. (1986) J. Pharmacol. Exp. Ther. 237, 558–562.PubMedGoogle Scholar
  13. 13.
    Labat, C., Ortiz, J.L., Norel, X., Gorenne, I., Verley, J., Abram, T.S., Cuthbert, N.J., Tudhope, S.R., Norman, P., Gardiner, P.J. and Brink, C. (1992) J. Pharmacol. Exp. Ther. 263, 800–805.PubMedGoogle Scholar
  14. 14.
    Weiss, J.W., Drazen, J.M., Coles, N., Mcfadden, E.R., Weiler, P.F., Corey, E.J., Lewis, R.A., and Austen, K.F. (1982) Science 216, 196–198.PubMedCrossRefGoogle Scholar
  15. 15.
    Weiss, J.W., Drazen, J.M., Mcfadden, E.R., Weiler, P.F., Corey, E.J., Lewis, R.A., and Austen, K.F. (1982) Trans. Assoc. Am. Physicians 93, 30–35.Google Scholar
  16. 16.
    Griffin, M., Weiss, J.W., Leitch, A.G., Mcfadden, E.R., Corey, E.J., Austen, K.F., and Drazen, J.M. (1983) N. Engl. J. Med. 308, 436–439.PubMedCrossRefGoogle Scholar
  17. 17.
    Barnes, N.C., Piper, P., and Costello, J.F. (1984) Prostaglandins 28, 629–630.CrossRefGoogle Scholar
  18. 18.
    Adelroth, E., Morris, M..M., Hargreave, F.E., and O’Byrne, P.M. (1986) N Engl. J. Med. 315, 480–484.PubMedCrossRefGoogle Scholar
  19. 19.
    O’Hickey, S.P., Arm, J.P., Rees, P.J., Spur, B.W., and Lee, T.H (1988) Eur. Respir. J. 1, 913–917.PubMedGoogle Scholar
  20. 20.
    Davidson, A.B., Lee, T.H., Scanlon, P.D., Solway, J., Mcfadden, E.R., Ingram, R.H., Corey, E.H., Austen, K.F., and Drazen, J.M. (1987) Am. Rev. Respir. Dis. 135, 333–337.PubMedGoogle Scholar
  21. 21.
    Jacques, C.A., Spur, B.W., Johnson, M. and Lee, T.H. (1991) Br. J. Pharmacol. 104, 859–866.PubMedGoogle Scholar
  22. 22.
    Krell, R.D. (1989) Pulmonary Pharmacology 2, 27–31.PubMedCrossRefGoogle Scholar
  23. 23.
    Phillips, G.D., Rafferty, P., Robinson, C, and Holgate, S.T. (1988) J. Pharmacol. Exp. Ther. 246, 732–738.PubMedGoogle Scholar
  24. 24.
    Drazen, J.M., Austen, K.F., Lewis, R.A., Clark, O.A., Goto, G., Marfat, A., and Corey, E.J. (1980) Proc. Nat. Acad. Sci. USA. 77, 4354–4358.PubMedCrossRefGoogle Scholar
  25. 25.
    Fleisch, J.H., Rinkema, L.E., and Baker, S.R. (1982) Life Sci. 31, 577–581.PubMedCrossRefGoogle Scholar
  26. 26.
    Krell, R.D., Tsai, B.S., Berdoulay, A., Barone, M., and Giles, R.E. (1983) Prostaglandins 25, 171–178.PubMedCrossRefGoogle Scholar
  27. 27.
    Berkowitz, B.A., Zabko-Potapovich, B., Volocik, R., and Gleason, J.G. (1984) J. Pharmacol. Exp. Ther. 229, 105–112.PubMedGoogle Scholar
  28. 28.
    Gause, G.E., Baker, R., and Cassin, S. (1988) Am. J. Physiol. 254, 120–125.Google Scholar
  29. 29.
    Secrest, R.J., Olsen, E.H., and Chapnick, B.M. (1985) Circ. Res. 57, 323–329.PubMedGoogle Scholar
  30. 30.
    Secrest, R.J., Ohlstein, E.H., and Chapnick, B.M. (1988) J. Pharmacol. Exp. Ther. 245, 47–52.PubMedGoogle Scholar
  31. 31.
    Sakuma, I., and Levi, R. (1988) Ann. N.Y. Acad. Sci. 524, 91–102.PubMedCrossRefGoogle Scholar
  32. 32.
    Ortiz, J.L., Gorenne, I., Cortijo, J., Seller, A., Labat, C, Sarria, B., Abram, T.S., Gardiner, P.J., Morcillo, E., and Brink, C. (1995) Br. J. Pharmacol. 115, 1382–1386.PubMedGoogle Scholar
  33. 33.
    Gorenne, 1., Norel, X., and Brink, C. (1996) Trends Pharmacol. Sci.. 17, 342–345.PubMedCrossRefGoogle Scholar
  34. 34.
    Foster, R.W., Okpalugo, B.I., and Small, R.C. (1984) Br. J. Pharmacol. 81, 499–507.PubMedGoogle Scholar
  35. 35.
    Cuthbert, N.J., Gardiner, P.J., Nash, K., and Poll, C.T. (1994) Am. J. Physiol. 266 (Lung Cell. Mol. Physiol). 10, L620-L627.Google Scholar
  36. 36.
    Duncan, P.G. and Douglas, J.S. (1984) J. Pharmacol. Exp. Ther. 228, 612–619.PubMedGoogle Scholar
  37. 37.
    Merritt, J.E., Armstrong, W.P., Benham, CD., Hallam, T.J., Jacob, R., Jaxa-Chamiec, A., Leigh, B.K., McCarthy, S.A., Moores, K.E., and Rink, T.J. (1990) Biochem. J. 271, 515–522.PubMedGoogle Scholar
  38. 38.
    Murray, R.K., and Kotlikoff, M.I. (1991) J. Physiol. Lond. 435. 123–144.PubMedGoogle Scholar
  39. 39.
    Fasolato, C, Pizzo, P., and Pozzan, T. (1990) J. Biol. Chem. 265, 20351–20355.PubMedGoogle Scholar
  40. 40.
    Soergel, D.G., Yasumoto, T., Daly, J.W. and Gusovsky, F. (1992) Molec. Pharmacol 41, 487–493.Google Scholar
  41. 41.
    Bjorck, T., and Dahlen, S-E. (1993) Pulmonary Pharmacol 6, 87–96.CrossRefGoogle Scholar
  42. 42.
    Gorenne, I., Labat, C, Gascard, J.P., Norel, X., Muller-Peddinghaus, R., Mohrs, K.H., Taylor, W.A., Gardiner, P.J., and Brink, C. (1994) J. Pharmacol. Exp. Ther 268, 868–872.PubMedGoogle Scholar

Copyright information

© Kluwer Academic/Plenum Publishers, New York 1999

Authors and Affiliations

  • Isabelle Gorenne
    • 1
  • Carlos Labat
    • 1
  • Xavier Norel
    • 1
  • Jean-Pierre Gascard
    • 1
  • Charles Brink
    • 1
  1. 1.CNRS ERS 566Centre Chirurgical Marie LannelongueLe Plessis RobinsonFrance

Personalised recommendations