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Models to Evaluate Health Risks Derived from Copper Exposure/Intake in Humans

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Copper Transport and Its Disorders

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 448))

Abstract

Copper (Cu) is essential for the survival of plants and animals. Animal and human studies have shown that Cu is involved in the function of several enzymes (Linder and Hazegh-Azam, 1996). Different studies have demonstrated that Cu is required for infant growth, host defense mechanisms, bone strength, red and white blood cell maturation, iron transport cholesterol and glucose metabolism, myocardial contractility, and brain development (Danks, 1988).

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References

  • Barnes, D.G. and Dourson, M.L. (1988). Reference dose (RfD): description and use in health risk assessments. Regul. Toxicol. Pharmacol. 8, 471–486.

    Article  PubMed  CAS  Google Scholar 

  • Beaumont, C., Simon, M., Fauchet, R., Hespel, J.P., Brissot, P., Genetet, B. and Bourel, M. (1979). Serum ferritin as a possible marker of the hemochromatosis allele. N. Engl. J. Med.. 301, 169–174

    Article  PubMed  CAS  Google Scholar 

  • Becking, G. (1996). Copper: essentiality and toxicity. IPCS News 10, 4–5.

    Google Scholar 

  • Berg, R., Lundh, S., Jansonn, G. and Rappe, A. (1981). Kopparforgiftning av dricksvattnet som orsak till diarre hos barn. Halsovardskontakt. 10, 6–8

    Google Scholar 

  • Bloomfield, J., Dixon, S.R. and McCredie, D.A. (1971). Potential hepatotoxicity of copper in recurrent hemodialysis. Arch. Int. Med. 128, 555–560.

    Article  Google Scholar 

  • Bothwell, T.H., Charlton, R.W., Cook, J.D. and Finch, C.A. (1979). Iron Metabolism In Man. (Oxford: Blackwell), pp. 245–255.

    Google Scholar 

  • Bowman, B.A. and Rishert, J.F. (1994). Comparison of the methodological approaches used in the derivation of recommended dietary allowances and oral reference doses for nutritionally essential elements. In: Risk Assessment Of Essential Elements, W. Mertz, CO. Abernathy, S.S. Olin, eds. (Washington, DC: ILSI Press), pp. 63–73.

    Google Scholar 

  • Center for Disease Control (CDC). (1975). Acute copper poisoning — Pennsylvania. Mortal. Morbid. Weekly Rep. 29, 99.

    Google Scholar 

  • Cousins, R.J. (1996) Zinc. In: Present Knowledge In Nutrition. E.E. Ziegler, L.J. Jr. Filer, eds. (Washington, DC: ILSI Press), pp. 293–306.

    Google Scholar 

  • Danks, D.M. (1988). Copper deficiency in humans. Annu. Rev. Nutr. 8, 235–257.

    Article  PubMed  CAS  Google Scholar 

  • Dourson, M.L. (1994). Methods for establishing oral reference doses. In: Risk Assessment Of Essential Elements, W. Mertz, CO. Abernathy, S.S. Olin, eds. (Washington, DC: ILSI Press), pp. 51–61.

    Google Scholar 

  • Dourson, M.L. and Stara, J.F. (1983). Regulatory history and experimental support of uncertainty (safety) factors. Regul. Toxicol. Pharmacol. 3, 224–238.

    Article  PubMed  CAS  Google Scholar 

  • Farrell, P.M., Bieri, J.G., Fratatoni, J.F., Wood, R.E. and Di Sant’Agnese, P.A. (1977). The occurrence and effects of human vitamin E deficiency. J. Clin. Invest. 60, 233–241.

    Article  PubMed  CAS  Google Scholar 

  • Fleet, J.C and Mayer, J. (1996). Discovery of the hemochromatosis gene will require rethinking the regulation of iron metabolism. Nutr. Rev. 54, 285–292.

    Article  PubMed  CAS  Google Scholar 

  • Frommer, D.J. (1976). Direct measurement of serum non-caeruloplasmin copper in liver disease. Clin. Chim. Acta. 68, 303–307.

    Article  PubMed  CAS  Google Scholar 

  • Goyer, R. (1994). Biology and nutrition of essential elements. In: Risk Assessment Of Essential Elements, W. Mertz, CO. Abernathy, S.S. Olin, eds. (Washington, DC: ILSI Press), pp. 13–19.

    Google Scholar 

  • Heresi, G., Castillo-Durán, C., Muñoz, C., Arévalo, M. and Schlesinger, L. (1985). Phagocytosis and immunoglobulin levels in hypocupremic infants. Nutr. Res. 5, 1327–1334.

    Article  Google Scholar 

  • Horslen, S.P., Tanner, M.S., Lyon, T.D.B., Fell, G.S. and Lowry, M.F. (1994). Copper associated childhood cirrhosis. Gut. 35, 1497–1500.

    Article  PubMed  CAS  Google Scholar 

  • International Atomic Energy Agency (IAEA). (1992). Human Dietary Intakes Of Trace Elements: A Global Literature Survey Mainly For The Period 1970-1991. I. Data List And Sources Of Information. (Vienna: IAEA).

    Google Scholar 

  • Joint FAO/WHO Expert Committee on Food Additives (JECFA). (1982). Toxicological Evaluation Of Certain Food Additives. World Health Organization Tech Rep Ser 683. (Rome: WHO), pp. 265–296.

    Google Scholar 

  • Knobeloch, L., Ziarnik, M., Howard, J., Theis, B., Farmer, D., Anderson, H. and Proctor, M. (1994). Gastrointestinal upsets associated with ingestion of copper-contaminated water. Environ. Health Perspect. 102, 958–961

    Article  PubMed  CAS  Google Scholar 

  • Linder, M.C. and Hazegh-Azam, M. (1996). Copper biochemistry and molecular biology. Am. J. Clin. Nutr. 63, 797S–811S.

    PubMed  CAS  Google Scholar 

  • Moynahan, E.J. (1974). Acrodermatitis enterophatica: a lethal inherited human zinc-deficiency disorder. Lancet ii, 399–400.

    Article  Google Scholar 

  • Müller, T., Feichtinger, H., Berger, H. and Müller, W. (1996). Endemic Tyrolean cirrhosis: an ecogenetic disorder. Lancet. 347, 877–880.

    Article  PubMed  Google Scholar 

  • National Research Council (NRC). (1989). Recommended Dietary Allowances. 10th ed. (Washington, DC: National Academy of Sciences), pp. 205–213.

    Google Scholar 

  • Nielsen, FH. and Milne, D.B. (1993). Oxidant stress effects on the clinical and nutritional deficiencies of trace elements. Int. J. Toxicol. Occupat. Environ. Health. 2, 59 (abstract).

    Google Scholar 

  • Olivares, M. and Uauy, R. (1996a). Copper as an essential element. Am. J. Clin. Nutr. 63, 791S–796S.

    PubMed  CAS  Google Scholar 

  • Olivares, M. and Uauy, R. (1996b). Limits of metabolic tolerance to copper and biological basis for present recommendations and regulations. Am. J. Clin. Nutr. 63, 846S–852S.

    PubMed  CAS  Google Scholar 

  • Pandit, A. and Bhave, S. (1996). Present interpretation of the role of copper in Indian childhood cirrhosis. Am. J. Clin. Nutr. 63, 830S–835S.

    PubMed  CAS  Google Scholar 

  • Scheinberg, I.H. and Sternlieb I. (1996). Wilson disease and idiopathic copper toxicosis. Am. J. Clin. Nutr. 63, 842S–845S.

    PubMed  CAS  Google Scholar 

  • Scheinberg, I.H. and Sternlieb, I. (1994). Is non-Indian childhood cirrhosis caused by excess dietary copper?. Lancet. 344, 1002–1004.

    Article  PubMed  CAS  Google Scholar 

  • Shaw, J.C.L. (1992). Copper deficiency in term and preterm infants. In: Nutritional Anemias. S.J. Fomon, S. Zlotkin, eds. Nestlé Nutrition Workshop Series Vol 30. (Vevey: Nestec Ltd, New York: Raven Press), pp. 105–119.

    Google Scholar 

  • Simpson, K.M., Morris, E.M. and Cook, J.D. (1981). The inhibitory effect of bran in iron absorption in man. Am. J. Clin. Nutr. 34, 1469–1478.

    PubMed  CAS  Google Scholar 

  • Spitalny, K.C., Brondum, J., Vogt, R.L., Sargent, H.E. and Kappel, S. (1984) Drinking water-induced intoxication in a Vermont family. Pediatr. 74, 1103–1106.

    CAS  Google Scholar 

  • Stekel, A., Olivares, M., Pizarro, F., Amar, M., Chadud, P., Cayazzo, M., Llaguno, S., Vega, V and Hertrampf, E. (1985). The role of ascorbic acid in the bioavailability of iron from infant foods. Int. J. Vitamin. Nutr. Res. 55(Suppl 27), 167–175.

    Google Scholar 

  • Stenhammar, L. (1979). Kopparintoxikation-en differentialdiagnos vi.d diarre hos barn. Lakartidningen. 76, 2618–2620.

    PubMed  CAS  Google Scholar 

  • Sternlieb, I. (1980). Copper and the liver. Gastroenterology. 78, 1615–1628.

    PubMed  CAS  Google Scholar 

  • Turnlund, J.R., Keyes, W.R., Anderson, H.L. and Acord, L.L. (1989). Copper absorption and retention in young men at three levels of dietary copper by use of the stable isotope 65Cu. Am. J. Clin. Nutr. 49, 870–878.

    PubMed  CAS  Google Scholar 

  • Uauy, R., Castillo-Durán, C., Fisberg, M., Fernandez, N. and Valenzuela, A. (1985). Red cell Superoxide dismutase activity as an index of human copper nutrition. J. Nutr. 115, 1650–1655.

    PubMed  CAS  Google Scholar 

  • US Environmental Protection Agency (USEPA), Environment Criteria and Assessment Office. (1985). Drinking Water Document For Copper (final draft). (EPA 600/X-84/190-l).(Cincinnati, OH: Environmental Protection Agency).

    Google Scholar 

  • US Environmental Protection Agency (USEPA), Environment Criteria and Assessment Office. (1987). Summary Review Of The Health Effects Associated With Copper. (EPA 600/8–87/00l).(Cincinnati, OH: Environmental Protection Agency).

    Google Scholar 

  • US Environmental Protection Agency (USEPA), Environmental Criteria and Assessment Office. (1993). The Integrated Risk Information System (IRIS) (online). (Cincinnati, OH, Environmental Protection Agency).

    Google Scholar 

  • van Campen, D.R. and Scaifi, P.U. (1967). Zinc interference with copper absorption in rats. J. Nutr. 91, 473–476.

    PubMed  Google Scholar 

  • WHO/FAO/IAEA. Copper. In: Trace Elements In Human Nutrition And Health. (Geneva: World Health Organization), pp. 123–143.

    Google Scholar 

  • Williams, M.L., Shott, R.J., O’Neal, P.L. and Oski, F.A. (1975). Role of dietary iron and fat on vitamin E deficiency anemia of infancy. N. Engl. J. Med. 292, 887–890.

    Article  PubMed  CAS  Google Scholar 

  • Wyllie, J. (1957). Copper poisoning at a cocktail party. Am. J. Public. Health. 47, 617.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Institute of Nutrition and Food Technology, University of Chile, Chile

    Manuel Olivares, Ricardo Uauy, Gloria Icaza & Mauricio González

Authors
  1. Manuel Olivares
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  2. Ricardo Uauy
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  3. Gloria Icaza
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  4. Mauricio González
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Editor information

Editors and Affiliations

  1. University of Salerno, Salerno, Italy

    Arturo Leone

  2. The Murdoch Institute for Research into Birth Defects, Royal Children’s Hospital, Parkville, Australia

    Julian F. B. Mercer

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© 1999 Springer Science+Business Media New York

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Olivares, M., Uauy, R., Icaza, G., González, M. (1999). Models to Evaluate Health Risks Derived from Copper Exposure/Intake in Humans. In: Leone, A., Mercer, J.F.B. (eds) Copper Transport and Its Disorders. Advances in Experimental Medicine and Biology, vol 448. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4859-1_2

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  • DOI: https://doi.org/10.1007/978-1-4615-4859-1_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7204-2

  • Online ISBN: 978-1-4615-4859-1

  • eBook Packages: Springer Book Archive

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