Importance of Drug Metabolism in Drug Discovery and Development
The metabolism of a drug can have important consequences on its therapeutic effect or its toxicity. For this reason, early assessments of metabolic pathways in man help to foresee interindividual variation in drug response and elimination due to metabolism. To address these issues, in vitro techniques based on human material are increasingly used as the basis for rational decisions during drug selection and development and to assess risk and potential drug interactions in man.
KeywordsCortisol Polycyclic Aromatic Hydrocarbon Testosterone Warfarin Caffeine
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