The F0F1-ATP Synthase in Cell Proliferation and Aging

  • Ferruccio Guerrieri


In normal conditions, the cellular ATP is provided mainly by the mitochondrial oxidative phosphorylation (OXPHOS), which is an integrated process between energy production by the respiratory chain and energy utilization by the F0F1ATP synthase complex of the inner mitochondrial membrane, with the remainder met by glycolysis. Oxidative phosphorylation capacity and the ATP needs vary from tissue to tissue. The brain is the organ with the highest demand for aerobic ATP, but heart muscle and kidney also have a high oxidative phosphorylation capacity (Wallace, 1992). The contribution of OXPHOS to the cellular energy demand changes, however, in the life span and in response to the physical activity (Papa, 1996).


Liver Regeneration Partial Hepatectomy Liver Mitochondrion Mitochondrial Oxidative Phosphorylation Adenine Nucleotide Translocase 
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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Ferruccio Guerrieri
    • 1
  1. 1.Institute of Medical Biochemistry and Chemistry, and Centre for the Study of Mitochondria and Energy MetabolismUniversity of BariBariItaly

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