Transient Synchronization of Propagating Discharges in Neocortical Slices
When cortical GABAA inhibition is blocked, a brief local stimulation above a certain intensity elicits a population discharge. In cortical slices1,2,3, this discharge consists of spatially and temporally localized neuronal activity, which may be viewed as an in vitro experimental model for focal epileptic discharge. The cellular equivalent of this traveling activity is characterized by a depolarization envelope, upon which a train of action potential rides. Studying pulse propagation is expected to uncover the relationship between cortical underlying circuitry and collective dynamical phenomena.
KeywordsDepression Coherence NMDA Bicuculline hMPA
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