Apoptosis Corrected Proliferation Fraction in Childhood All is Related to Karyotype
Tumour doubling time, a parameter in drug sensitivity testing, reflects both cell proliferation and apoptosis. Variable apoptosis fractions may explain the poor correlation of S-fraction and drug response. DNA aneuploidy (reflecting intrinsic DNA instability) may, by increasing apoptosis, affect drug response.
KeywordsApoptosis karyotype childhood ALL cell proliferation drug response
Unable to display preview. Download preview PDF.
- 3.Cotter TG, Lennon SV, Glynn JG, Martin SJ. Cell death via apoptosis and its relationship to growth, development, and differentiation of both tumour and normal cells. Anticancer Res 1990; 1:1153–1160.Google Scholar