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Apoptosis Corrected Proliferation Fraction in Childhood All is Related to Karyotype

  • Lynne M. Ball
  • Allen F. Pyesmany
  • Margaret Yhap
  • Christopher L. Lannon
  • M. Henry
  • Krista Laybolt
  • D. Christie Riddell
  • Dick van Velzen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 457)

Abstract

Tumour doubling time, a parameter in drug sensitivity testing, reflects both cell proliferation and apoptosis. Variable apoptosis fractions may explain the poor correlation of S-fraction and drug response. DNA aneuploidy (reflecting intrinsic DNA instability) may, by increasing apoptosis, affect drug response.

Keywords

Apoptosis karyotype childhood ALL cell proliferation drug response 

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References

  1. 1.
    Sarraf CE, Bowen ID. Proportions of mitotic and apoptotic cells in a range of untreated experimental tumours. Cell Tissue Kinet, 1988; 21:45–49.PubMedGoogle Scholar
  2. 2.
    Du M, Singh N, Husseuin A, Isaacson PG, Pan L. Positive correlation between apoptotic and proliferative indices in gastrointestinal lymphomas of mucosa-associated lymphoid tissue (MALT). J Pathol 1996; 178:379–384.PubMedCrossRefGoogle Scholar
  3. 3.
    Cotter TG, Lennon SV, Glynn JG, Martin SJ. Cell death via apoptosis and its relationship to growth, development, and differentiation of both tumour and normal cells. Anticancer Res 1990; 1:1153–1160.Google Scholar
  4. 4.
    Wyllie AH. Apoptosis and regulation of cell numbers in normal and neoplastic tissues: an overview. Cancer Met Rev 1992; 11:95–103.CrossRefGoogle Scholar
  5. 5.
    Moul JW, Bettencourt MC, Sesterhenn IA, Mostofi FK, McLeod DG, Srivastava S, Bauer JJ. Protein expression of p53, bcl-2, and Ki-67 (MIB-1) as prognostic biomarkers in patients with surgically treated, clinically localized prostate cancer. Surgery 1996; 120:159–167.PubMedCrossRefGoogle Scholar
  6. 6.
    Secker-Walker LM, Swansbury GJ, Hardisty RM. Cytogenetics of acute lymphoblastic leukaemia in children as a factor in the prediction of long term survival. Br J Haematol, 1982, 52:389–399.PubMedCrossRefGoogle Scholar
  7. 7.
    Hicsonmez G, Erdemli E, Tekelioglu M, Tuncer AM, et al. Morphological evidence of apoptosis in childhood acute myeloblastic leukaemia treated with high dose methyl prednisolone. Leuk Lymphoma 1996, 22:91–96.PubMedCrossRefGoogle Scholar
  8. 8.
    Tsangaris GT, Tzortzatou-Stathopoulou F. Development of a quantitative method for the study of apoptosis in peripheral blood. In Vivo, 1996, 10:435–443.PubMedGoogle Scholar
  9. 9.
    Coustan-Smith E, Kitenaka A, Pui CH, McNinch L, et al. Clinical relevance of Bcl2 overexpression in childhood acute lymphoblastic leukaemia. Blood, 1996, 87:1140–1146.PubMedGoogle Scholar
  10. 10.
    Baxter GD, Collins RJ, Harmon BV, Kumar S, et al. Cell death by apoptosis in acute leukaemia. J Pathol, 1989, 158:123–129.PubMedCrossRefGoogle Scholar
  11. 11.
    Thiele J, Zirbes TK, Lorenzen J, Kvasnicka HM, et al. Haemopoietic turnover index in reactive and neoplastic bone marrow lesions quantification by apoptosis and PCNA labelling. Ann Haematol, 1997, 75:33–39.CrossRefGoogle Scholar
  12. 12.
    Cascavilla N, Musto P, Derina G, Ladogana S, et al. Are early and late T-acute lymphoblastic leukaemia different diseases. A Single Centre Study of 34 patients. Leuk Lymphoma, 1996, 21:437–442.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Lynne M. Ball
    • 1
  • Allen F. Pyesmany
    • 1
  • Margaret Yhap
    • 1
  • Christopher L. Lannon
    • 1
  • M. Henry
    • 1
  • Krista Laybolt
    • 1
  • D. Christie Riddell
    • 1
  • Dick van Velzen
    • 1
  1. 1.Department of PathologyDalhousie University, IWK Grace Health CentreHalifaxCanada

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