Gallbladder Dysmotility

  • Glen A. Lehman


The role of the gallbladder is to store and concentrate bile during the interdigestive intervals and to deliver the concentrated bile to the duodenum during feeding. The neurohumoral regulation of these events is only partially understood. The stimulation of the duodenal mucosa by intraluminal long chain fats and aminoacids releases cholecystokinin. This peptide is the major factor which causes gallbladder contraction. Although cholinergic and sympathetic innervation may play a role, truncal vagotomy and celiac ganglionectomy do not appear to alter gallbladder function. Numerous conditions and drugs can adversely affect gallbladder motility and this list includes pregnancy, obesity, prolonged fasting, estrogen administration, octreotide, anticholinergics, bile supersaturated with cholesterol, presence of gall stones, octreotide, and spinal injuries (1).


Cystic Duct Acalculous Cholecystitis Truncal Vagotomy Acute Acalculous Cholecystitis Biliary Dyskinesia 
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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Glen A. Lehman
    • 1
  1. 1.Division of Gastroenterology/Hepatology Department of MedicineIndiana University Medical CenterUSA

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