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Stereoselective Routes to Conjugated Polyenes

  • Francesco Naso

Abstract

Our work on sequential cross-coupling reactions has shown that 1-bromo-2-phenylthioethenes 1 and 2 represent very useful building blocks for the construction of stereodefined 1,2-disubstituted ethenes.1 The methodology is based upon the selective substitution of the halogen atom in the first step by reaction with Grignard reagents in the presence of Ni or Pd complexes followed by the substitution of the phenylthio group. Good yields are obtained. The stereospecificity is higher than or equal to 99% in the case of E-isomers and slightly lower in the case of Z-isomers.

Keywords

Light Emit Diode Grignard Reagent Acylation Reaction Boron Derivative Boronic Acid Derivative 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Francesco Naso
    • 1
  1. 1.Centro CNR di Studio sulle Metodologie Innovative di Sintesi Organiche, Dipartimento di ChimicaUniversità degli Studi di BariBariItaly

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