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Catalytic Enantioselective Reactions of Aldimines Using Chiral Lewis Acids

  • Shū Kobayashi

Abstract

Asymmetric Mannich-type reactions provide useful routes for the synthesis of optically active β-amino ketones or esters, which are versatile chiral building blocks in the preparation of many nitrogen-containing biologically important compounds. While several diastereoselective Mannich-type reactions have already been reported, very little is known about the enantioselective versions. In addition, asymmetric Mannich-type reactions using small amounts of chiral sources have not been reported, when we started these research efforts.

Keywords

Enantiomeric Excess Amino Alcohol Cerium Ammonium Nitrate Amino Ester Zirconium Catalyst 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Shū Kobayashi
    • 1
  1. 1.Graduate School of Pharmaceutical SciencesThe University of TokyoHongo, Bunkyo-ku, TokyoJapan

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