de Novo and Secondary AML Cells Differ in Their Kinetic Response to HGF Priming
This study has assessed the effect of haemopoietic growth factor (HGF) priming on the S-phase activity of cells from patients with de novo AML (n = 33) or AML secondary to prodromal myelodysplasia (n = 15). An immunofluorescent ligand binding assay was used to determine the occurrence of receptors for HGFs under scrutiny, namely, G-CSF, GM-CSF, IL-3, and SCF. In order to determine whether invitro kinetic or receptor data might correlate with clinical outcome, data from 36 AML samples was subjected to multivariate discriminant analysis using a quadratic discriminant function.
KeywordsEurope Lymphoma Leukemia Neutropenia Cytosine
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