de Novo and Secondary AML Cells Differ in Their Kinetic Response to HGF Priming

  • M. A. Smith
  • C. J. Pallister
  • R. W. Luxton
  • C. R. J. Singer
  • J. G. Smith
Chapter

Abstract

This study has assessed the effect of haemopoietic growth factor (HGF) priming on the S-phase activity of cells from patients with de novo AML (n = 33) or AML secondary to prodromal myelodysplasia (n = 15). An immunofluorescent ligand binding assay was used to determine the occurrence of receptors for HGFs under scrutiny, namely, G-CSF, GM-CSF, IL-3, and SCF. In order to determine whether invitro kinetic or receptor data might correlate with clinical outcome, data from 36 AML samples was subjected to multivariate discriminant analysis using a quadratic discriminant function.

Keywords

Europe Lymphoma Leukemia Neutropenia Cytosine 

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References

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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • M. A. Smith
    • 1
    • 3
  • C. J. Pallister
    • 2
  • R. W. Luxton
    • 2
  • C. R. J. Singer
    • 1
  • J. G. Smith
    • 2
  1. 1.Department of HaematologyRoyal United Hospital NHS TrustBathUK
  2. 2.Faculty of Applied SciencesUniversity of West of EnglandBristolUK
  3. 3.Bone Marrow Laboratory, Department of HaematologyRoyal United NHS TrustBathUK

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