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Iron and Erythropoiesis

Lessons from Anemic Mice
  • Nancy C. Andrews
  • Mark D. Fleming
Chapter

Abstract

Iron deficiency and iron overload disorders are among the most common diseases afflicting modern man. Iron deficiency affects up to one billion individuals worldwide. Women and children are most commonly iron deficient, as a result of increased iron needs attributable to regular blood loss and rapid growth, respectively. Untreated iron deficiency in infants and toddlers can lead to irreversible cognitive deficits. Internationally, most iron deficiency can be traced to dietary insufficiency or subacute gastrointestinal hemorrhage associated with chronic parasitic infections. Rare patients have inherited defects in iron absorption or iron utilization. Iron deficiency is usually treatable with oral iron salts. While this treatment is inexpensive, it may be difficult to achieve compliance, because iron repletion takes several months to complete.

Keywords

Iron Deficiency Iron Overload Iron Uptake Microcytic Anemia Intestinal Iron Absorption 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Nancy C. Andrews
    • 1
    • 2
  • Mark D. Fleming
    • 1
    • 2
  1. 1.Howard Hughes Medical Institute and Division of Hematology/OncologyChildren’s HospitalUSA
  2. 2.Departments of Pathology and PediatricsHarvard Medical SchoolBostonUSA

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