Genesis and Progression of Gastric Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma

  • Ming-Qing Du
  • Peter G. Isaacson
Chapter

Abstract

MALT lymphomas typically arise in extranodal tissues, such as the stomach, which are normally devoid of lymphoid tissue but which have acquired MALT as the result of a chronic inflammatory disorder. In the stomach this process is exemplified by chronic gastritis caused by infection with H. pylori. The lymphoma is at first confined to the mucosa and later progresses with deeper invasion of the gastric wall, local and systemic dissemination and finally, transformation to high grade lymphoma. In its early phase the growth of gastric MALT lymphoma is stimulated by H. pylori specific T-cells and to a lesser extent, by an autoantigen. It is in this phase that eradication of H pylori may result in clinical regression of the lymphoma. Molecular genetic studies have suggested that early events in the evolution of gastric MALT lymphoma from “acquired” MALT include “genetic instability” as indicated by replication error phenotype, t(ll;14), trisomy 3, partial p53 inactivation, and c-myc mutation. Later molecular events include, probably t(l;14) and other uncharacterised, which cause complete malignant transformation and result in escape of T-cell dependency. Finally, further genetic events such as complete inactivation of the tumour suppressor genes p53and p16, and possible activation of c-myc oncogene by translocation or other undetermined abnormalities can result in high grade transformation.

Keywords

gastric MALT lymphoma biology pathogenesis 

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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Ming-Qing Du
    • 1
  • Peter G. Isaacson
    • 1
  1. 1.Department of HistopathologyUniversity College London Medical SchoolLondonUK

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