Linoleic Acid Metabolites in Health and Disease

  • Michael R. Buchanan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 469)


A common factor in the progression of metastasis, atherosclerosis and inflammation is excessive cell growth prompted by both endogenous or exogenous stimuli; e.g. ocogenes, cytokines and thrombin. Excessive cell growth in all of these pathologic responses requires multiple cell cell interactions. There is an abundance of literature suggesting that arachidonic acid metabolites derived from both the cyclooxygenase and lipoxygenase pathways, influence these processes, but it is only recently that our attention has included the importance of linoleic acid metabolism and the relative roles of linoleic and arachidonic acid metabolites in these disease processes.


Linoleic Acid Arachidonic Acid Arachidonic Acid Metabolite Primary Tumour Growth Arachidonic Acid Level 
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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Michael R. Buchanan
    • 1
  1. 1.Department of PathologyMcMaster UniversityHamilton, OntarioCanada

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