Lipid Mediators Stimulate Reactive Oxygen Species Formation in Immortalized Human Keratinocytes
Cell signaling is accompanied by rapid remodeling of membrane lipids by activated phospholipases (PLA2, PLC, PLD and sphingomyelinase) with the generation of bioactive lipids that can serve as intra- and/or extracellular mediators (Serhan, et al., 1996). These lipid mediators include eicosanoids, platelet activating factor (PAF), diacyl glycerides, lyso-phosphatidylcholine (LPC), phosphatidic acid (PA), lyso-PA, ceramide and other newly-discovered autacoids. They are important in a wide range of cell-cell communication processes, such as host defense, inflammation, ischemia reperfusion and homeostasis.
KeywordsPhosphatidic Acid Phosphatidic Acid HaCaT Cell Reactive Oxygen Species Formation Lipid Mediator
Unable to display preview. Download preview PDF.