Abstract
Cell signaling is accompanied by rapid remodeling of membrane lipids by activated phospholipases (PLA2, PLC, PLD and sphingomyelinase) with the generation of bioactive lipids that can serve as intra- and/or extracellular mediators (Serhan, et al., 1996). These lipid mediators include eicosanoids, platelet activating factor (PAF), diacyl glycerides, lyso-phosphatidylcholine (LPC), phosphatidic acid (PA), lyso-PA, ceramide and other newly-discovered autacoids. They are important in a wide range of cell-cell communication processes, such as host defense, inflammation, ischemia reperfusion and homeostasis.
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Goldman, R., Moshonov, S., Zor, U. (1999). Lipid Mediators Stimulate Reactive Oxygen Species Formation in Immortalized Human Keratinocytes. In: Honn, K.V., Marnett, L.J., Nigam, S., Dennis, E.A. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4. Advances in Experimental Medicine and Biology, vol 469. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4793-8_60
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DOI: https://doi.org/10.1007/978-1-4615-4793-8_60
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