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Local Anesthetic Effects on TXA2 Receptor Mediated Platelet Aggregation Using Quenched Flow Aggregometry

  • Christian W. Honemann
  • Bernard Lo
  • Jo S. Erera
  • Renate Polanowska-Grabowska
  • Adrean R. L. Gear
  • Marcel Durieux
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 469)

Abstract

Thrombembolic complications are common during and after surgery, and appear to result from hyper-coagulation and hypo-perfusion (the latter often induced by vasoconstriction). After major orthopedic or urologic surgery, deep venous thrombosis is reported to occur in 30 – 80% of patients.1,2 Similarly, myocardial ischemia1, induced by microthombosis and/or coronary vasoconstriction, is frequent.3,4 The mechanisms for this response are poorly understood, but inflammatory mediators — released in response to surgical trauma and inducing thrombosis and vasoconstriction — are likely to be pivotal.

Keywords

Platelet Aggregation Local Anesthetic K562 Cell Deep Venous Thrombosis Induce Platelet Aggregation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Christian W. Honemann
    • 1
    • 2
  • Bernard Lo
    • 2
  • Jo S. Erera
    • 2
  • Renate Polanowska-Grabowska
    • 3
  • Adrean R. L. Gear
    • 3
  • Marcel Durieux
    • 2
  1. 1.Klinik and Poliklinik fur Anasthesiologie and Operative IntensivmedizinWestfalische Wilhelms Universitat MunsterMunsterGermany
  2. 2.Department of AnesthesiologyUniversity of Virginia Health Science CenterCharlottesvilleUSA
  3. 3.Department of BiochemistryUniversity of Virginia Health Sciences CenterCharlottesvilleUSA

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