Cytokine Induced Regulation of 15-Lipoxygenase and Phospholipid Hydroperoxide Glutathione Peroxidase in Mammalian Cells

  • Kerstin Schnurr
  • Roland Brinckmann
  • Hartmut Kühn
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 469)


Lipid peroxidation has been implicated in the pathogenesis of various diseases such as cancer, atherosclerosis, and neurodegenarative disorders (Louvel et al., 1997). Under resting conditions the intracellular peroxide level of mammalian cells is rather low (Weitzel and Wendel, 1993) and this may be due to the high reducing capacity of most mammalian cells. However, during cell activation the cellular peroxide tone may be increased leading to membrane damage and even cell death. The cellular peroxide tone is a steady state concentration which depends inter alia on the expression of pro- and anti-oxidative enzymes. With respect to lipid peroxidation 15-lipoxygenases (15-LO’s) and the phospholipid hydroperoxide glutathione peroxidase (PH-GPx) constitute opposite enzymes in the cellular metabolism of hydroperoxy ester lipids.


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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Kerstin Schnurr
    • 1
  • Roland Brinckmann
    • 1
  • Hartmut Kühn
    • 1
  1. 1.Institute of BiochemistryUniversity Clinics Charité, Humboldt UniversityBerlinGermany

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