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α-Galactosyl-Bearing Epitopes as Potent Immunogens in Chagas’ Disease and Leishmaniasis

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α-Gal and Anti-Gal

Part of the book series: Subcellular Biochemistry ((SCBI,volume 32))

Abstract

Anti-α-galactosyl (anti-Gal) is a human natural antibody which constitutes as much as 1% of circulating IgG and which interacts specifically with the carbohydrate epitope Galα 1–3 Galβ1– 4GlcNac-R (termed the α-gal epitope). This natural antibody is unique among known human natural antibodies because of its unusually high concentration in the serum (30–100 μg/ ml)( Avila et al., 1989; Davin et al., 1987; Galili et al., 1984), and is presence in all humans (Galili et al., 1984). The only other mammals producing anti-Gal are Old World monkeys and apes (Galili et al., 1987b).

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  1. Instituto de Biomedicina, 1010A, Caracas, Venezuela

    José Luis Avila

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  1. José Luis Avila
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  1. MCP-Hahnemann School of Medicine, Allegheny University of the Health Sciences, Philadelphia, Pennsylvania, USA

    Uri Galili

  2. Institute of Biomedicine, Caracas, Venezuela

    José Luis Avila

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© 1999 Springer Science+Business Media New York

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Avila, J.L. (1999). α-Galactosyl-Bearing Epitopes as Potent Immunogens in Chagas’ Disease and Leishmaniasis. In: Galili, U., Avila, J.L. (eds) α-Gal and Anti-Gal. Subcellular Biochemistry, vol 32. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4771-6_8

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  • DOI: https://doi.org/10.1007/978-1-4615-4771-6_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7160-1

  • Online ISBN: 978-1-4615-4771-6

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