Anti-Gal, α-Gal Epitopes, and Xenotransplantation

  • Takaaki Kobayashi
  • David K. C. Cooper
Part of the Subcellular Biochemistry book series (SCBI, volume 32)


Significant progress in clinical transplantation has been achieved through the development of improved immunosuppressive therapy during the past two decades. Transplantation is clearly established as the treatment of choice for many patients suffering from end-stage organ failure. Although the number of organ donors becoming available has slowly increased, the relative shortage of organ donors caused by the extended indications for transplantation has become critical. Attention is now being focused on xenotransplantation—using animal organs, tissues or cells—as a potential and promising solution to this serious problem (Cooper, 1993a).


Natural Antibody Hyperacute Rejection Xenograft Rejection Antiidiotypic Antibody Porcine Endothelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Takaaki Kobayashi
    • 1
  • David K. C. Cooper
    • 2
  1. 1.Department of Surgery 11Nagoya University School of MedicineNagoyaJapan
  2. 2.Transplantation Biology Research CenterMassachusetts General Hospital/Harvard Medical SchoolBostonUSA

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