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Conclusions and Recommendations

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Perspectives on Biologically Based Cancer Risk Assessment

Part of the book series: Nato · Challenges of Modern Society ((NATS,volume 23))

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Abstract

The present report addresses several key issues in quantitative cancer risk assessment pertaining to the dose- response analysis of initiator and promoter carcinogens. Most problems addressed in this report fall into one of the following categories of questions:

  1. 1.

    What does each source of experimental data contribute to our knowledge and ability to model?

  2. 2.

    What kinds of information are needed to develop a biologically based model?

  3. 3.

    How does linearity enter into empirical models and biologically based models?

  4. 4.

    How does a biologically based model help us understand intraspecies variability?

  5. 5.

    How does a biologically based model help us understand interspecies variability?

  6. 6.

    What are the uncertainties associated with a biologically based model?

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Author information

Authors and Affiliations

  1. University of Evora, Evora, Portugal

    J. J. Amaral-Mendes

  2. U.S. Environmental Protection Agency, Washington, DC, USA

    J. V. Cogliano

  3. National Centre for Scientific Research “Demokritus”, Athens, Greece

    A. Kappas

  4. Department of Statistics, Athens University of Economics and Business, Athens, Greece

    C. Kitsos

  5. Rijksinstituut voor Volksgezondheid en Milieuhygiene, Bilthoven, The Netherlands

    E. D. Kroese

  6. Fred Hutchinson Cancer Research Center, Seattle, USA

    E. G. Luebeck

  7. Oncology Department, Jolimont Hospital (honorary), La Louvière, Belgium

    E. Pluygers

  8. Tulane University Medical Center, New Orleans, USA

    C. Travis & K. Watanabe

  9. Institute of Statistics, University of Bremen, Bremen, Germany

    W. Wosniok

  10. National Institute of Health, Rome, Italy

    G. A. Zapponi

Authors
  1. J. J. Amaral-Mendes
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  2. J. V. Cogliano
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  3. A. Kappas
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  4. C. Kitsos
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  5. E. D. Kroese
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  6. E. G. Luebeck
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  7. E. Pluygers
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  8. C. Travis
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  9. K. Watanabe
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  10. W. Wosniok
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  11. G. A. Zapponi
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Editor information

Editors and Affiliations

  1. United States Environmental Protection Agency, Washington, DC, USA

    Vincent James Cogliano

  2. Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

    E. Georg Luebeck

  3. National Institute of Health, Rome, Italy

    Giovanni A. Zapponi

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© 1999 Springer Science+Business Media New York

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Amaral-Mendes, J.J. et al. (1999). Conclusions and Recommendations. In: Cogliano, V.J., Luebeck, E.G., Zapponi, G.A. (eds) Perspectives on Biologically Based Cancer Risk Assessment. Nato · Challenges of Modern Society, vol 23. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4741-9_9

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  • DOI: https://doi.org/10.1007/978-1-4615-4741-9_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7149-6

  • Online ISBN: 978-1-4615-4741-9

  • eBook Packages: Springer Book Archive

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