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Replicative Senescence in Human Uroepithelial Cells

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Advances in Bladder Research

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References

  1. Hayflick L, Moorhead PS. The serial cultivation of human diploid cell strains. Experimental Cell Research, 25:585–621, 1961.

    Article  PubMed  CAS  Google Scholar 

  2. Campisi J. Replicative senescence: An old lives’ tale? Cell, 84: 497 500,1996

    Google Scholar 

  3. Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW. Oncogenic ras provokes premature Cell senescence associated with accumulation of p53 and p16INK4a. Cell, 88:593–602, 1997.

    Article  PubMed  CAS  Google Scholar 

  4. Smith JR and Pereira-Smith OM. Replicative Senescence: Implications for in vivo aging and tumor suppression. Science, 273:63–67, 1996.

    Article  PubMed  CAS  Google Scholar 

  5. Dimri GP, Campisi J. Molecular and cell biology of replicative senescence. Cold Spring Harbor Symposia on Quantitative Biology, Vol. LIX, Cold Spring Harbor Laboratory Press, pp 67–73, 1994.

    Google Scholar 

  6. Kulju KS, Lehman JM. Increased p53 protein associated with aging in human diploid fibroblasts. Experimental Cell Research 217(2):336–45, 1995 Apr.

    Article  PubMed  CAS  Google Scholar 

  7. Sherr CJ, Roberts JM. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes & Development, 9:1149–1163, 1995.

    Article  CAS  Google Scholar 

  8. Hara E, Smith R, Parry D, Tahara H, Stone S, Peters G. Regulation of p16CDKN2 expression and Its implication for cell immortalization and senescence. Molecular and Cellular Biology, 16:859–867, 1996.

    PubMed  CAS  Google Scholar 

  9. Loughran O, Malliri A, Owens D, Gallimore PH, Stanley MA, Ozanne B, Frame MC, Parkinson EK. Association of CDKN2A/p16INK4A with head and neck keratinocyte replicative senescence: relationship of dysfunction to immortality and neoplasia. Oncogene, 13:561–568, 1996.

    PubMed  CAS  Google Scholar 

  10. Reznikoff CA, Yeager TR, Belair CD, Savelieva E, Puthenveettil JA, Stadler W M. Elevate p16 at senescence and loss of p16 at immortalization in Human Papillomavirus 16 E6, but not E7, transformed human uroepithelial cells. Cancer Research 56:2886–2890, 1996.

    PubMed  CAS  Google Scholar 

  11. Barrett JC, Annab LA, Alcorta D, Preston G, Vojta P, Yin Y. Cellular Senescence and Cancer. Cold Spring Harbor Symposia on Quantitative Biology, Vol. LIX, Cold Spring Harbor Laboratory Press, pp 411–417, 1994.

    Google Scholar 

  12. Uhrbom L, Nister M, Westermark B. Induction of senescence in human malignant glioma cells by p16INK4A. Oncogene 15(5):505–14, 1997 July 31.

    Article  PubMed  CAS  Google Scholar 

  13. Xu H-J, Zhou Y, Ji W, Perng G-S, Kruzelock R, Kong C-T, Bast RC, Mills GB, Li J, Hu S-X. Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition. Oncogene 15:2589–2596, 1997.

    Article  PubMed  CAS  Google Scholar 

  14. Kamijo T, Zindy F, Roussel MF, Quelle DE, Downing JR, Ashmun RA, Grosveld G, Sherr CJ. Tumor suppression at the mouse INK4A locus mediated by the alternative reading frame product p19ARF. Cell, 91:649–659, 1997.

    Article  PubMed  CAS  Google Scholar 

  15. Allsop RC, Vaziri H, Patterson C, Goldstein S, Younglais, EV, Futcher AV, Greider CW and Harley CB. Telomere length predicts replicative capacity of human fibroblasts. Proc. Natl. Acad. Sc., 89:10114–10118, 1992.

    Article  Google Scholar 

  16. Harley CB, Sherwood SW. Telomerase, checkpoints and cancer. Cancer Surveys 29:263–84, 1997.

    PubMed  CAS  Google Scholar 

  17. Belair CD, Yeager TR, Lopez PM, Reznikoff CA. Telomerase activity: A biomarker of cell proliferation, not malignant transformation. Proc Natl Acad Sci USA 94:13677–13682, 1997.

    Article  PubMed  CAS  Google Scholar 

  18. Puthenveettil JA, Frederickson SM and Reznikoff CA. Apoptosis in human papillomavirus 16 E7 - but not E6-immortalized human uropeithelial cells. Oncogene, 13:1123–1131, 1996.

    PubMed  CAS  Google Scholar 

  19. Yingling JM, Datto MB, Wong C, Frederick JP, Liberati NT and Wang XF. Tumor suppressor Smad4 is transforming growth factor beta-inducible DNA binding protein. Molecular and Cellular Biology, 17:7019–7028, 1997.

    PubMed  CAS  Google Scholar 

  20. Mu XC and Higgins PJ. Differential growth state-dependent regulation of plasminogen activator inhibitor type-1 expression in senescent IMR-90 human diploid fibroblasts. Journal of Cellular Physiology 165(3):647–57, 1995.

    Article  PubMed  CAS  Google Scholar 

  21. Reznikoff CA, Belair C, Savelieva E, Zhai Y, Pfieffer K, Yeager T, Thompson KJ, DeVries S, Bindley C, Newton MA, Sekhon G and Waldman F. Long term genome stability and minimal genotypic and phenotypic alterations in HPV 16 E7-, but not E6-, immortalized human uroepithelial cells. Genes & Development, 8:2227–2240, 1994.

    Article  CAS  Google Scholar 

  22. Yeager TR, DeVries S, Jarrard DF, Kao C, Nakada SY, Moon TD, Bruskewitz R, Stadler WM, Meisner LF, Gilchrist KW, Newton MA, Waldman FM, Reznikoff CA. Overcoming cellular senescence in human cancer pathogenesis. Genes & Development 12:163–174, 1998.

    Article  CAS  Google Scholar 

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Puthenveettil, J.A., Burger, M.S., Reznikoff, C.A. (1999). Replicative Senescence in Human Uroepithelial Cells. In: Baskin, L.S., Hayward, S.W. (eds) Advances in Bladder Research. Advances in Experimental Medicine and Biology, vol 462. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4737-2_7

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  • DOI: https://doi.org/10.1007/978-1-4615-4737-2_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7147-2

  • Online ISBN: 978-1-4615-4737-2

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