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Enzymology and Molecular Biology of Carbonyl Metabolism 7 pp 1–7Cite as

The Big Book of Aldehyde Dehydrogenase Sequences

An Overview of the Extended Family

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 463))

Abstract

Traditionally, research on aldehyde dehydrogenases (ALDHs, EC 1.2.1) has focused on three groups: class 1, 2, and 3 ALDHs. Class 1 and 2 ALDHs are very closely related homotetramers and both participate in ethanol metabolism, though class 1 ALDHs can oxidize wide range of metabolites, including retinal (reviewed Lindahl, 1982; Yoshida et al., 1). Class 3 ALDHs appear at first glance to be highly divergent from the other 2 classes. Class 3 ALDHs share only about 25% sequence identity with class 1 and 2 ALDHs and are homodimers. However, in main-chain folding, the structures of the class 2 and 3 monomers are nearly identical (Hempel et al., 1999)

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Author information

Authors and Affiliations

  1. Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, 15261, USA

    John Perozich

  2. Pittsburgh Supercomputing Center, Carnegie-Mellon University, Pittsburgh, Pennsylvania, 15213, USA

    Hugh Nicholas

  3. Department of Biochemistry and Molecular Biology, University of South Dakota, Vermillion, South Dakota, 57069, USA

    Ronald Lindahl

  4. Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, 15260, USA

    John Hempel

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  1. John Perozich
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  2. Hugh Nicholas
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  3. Ronald Lindahl
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  4. John Hempel
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Editor information

Editors and Affiliations

  1. Purdue University, West Lafayette, Indiana, USA

    Henry Weiner

  2. Philipps University of Marburg, Marburg, Germany

    Edmund Maser

  3. Indiana University School of Medicine, Indianapolis, Indiana, USA

    David W. Crabb

  4. University of South Dakota School of Medicine, Vermillion, South Dakota, USA

    Ronald Lindahl

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Perozich, J., Nicholas, H., Lindahl, R., Hempel, J. (1999). The Big Book of Aldehyde Dehydrogenase Sequences. In: Weiner, H., Maser, E., Crabb, D.W., Lindahl, R. (eds) Enzymology and Molecular Biology of Carbonyl Metabolism 7. Advances in Experimental Medicine and Biology, vol 463. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4735-8_1

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  • DOI: https://doi.org/10.1007/978-1-4615-4735-8_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7146-5

  • Online ISBN: 978-1-4615-4735-8

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