Mechanisms of Copper Chaperone Proteins
Little is known about the chemistry and biology involved in getting a metal such as copper (Cu) to the right place in a cell. Recently, several members of an emerging class of proteins have been proposed to play a role in guiding and protecting metal ions inside cells, and ultimately delivering these cofactors to specific targets. The copper escort function for one of the yeast proteins, Atxl, has been established (Pufahl et al., 1997). A similar function has been proposed for another yeast protein, Lys7, which shares some sequence similarity to Atxl, but is thought to deliver copper to another target within the cell (Culotta et al., 1997). This review summarizes recent insights into the biological chemistry of these two prototypical metal ion chaperone proteins.
KeywordsZinc Nickel Mercury Chrome Superoxide
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