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Laser-Assisted Optical Rotational Red Cell Analyzer (LORCA) in Clinical Practice

Hemorheological Kinetics and Tissue Oxygenation
  • G. Cicco
  • A. J. van der Kleij
  • G. D. Stingi
  • M. S. Tarallo
  • A. Pirrelli
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 471)

Abstract

Relevant hemodynamic changes in arterial hypertension (i.e. vasoconstriction induced by an organic arterial wall thickening or a functionally induced vasospasm) can lead to increased peripheral resistance. In the microvasculature of hypertensive subjects it is often possible to detect decreased peripheral perfusion together with hemorheological alterations (such as the presence of red blood cell aggregates, decreased erythrocyte deformability). These hemorheological changes can raise blood pressure (increasing the resistance of the blood flow in the microvasculature) and may finally induce a reduction in peripheral tissue oxygenation. These conditions are negatively influenced by lipoido-proteinosis, diabetes and smoking, which very important risk factors in hypertensives for acute myocardial infarction, transient ischemic attack, ictus, and peripheral occlusive arterial disease (Cesarone, 1992; Cicco, 1993, 1998). It has been shown that a good pharmacological control of the blood pressure and the lipoidoproteinosis influence the hemorheological patterns in the microvasculature, improving peripheral perfusion and tissue oxygenation (Cicco, 1994, 1995, 1997).

Keywords

Tissue Oxygenation Peripheral Occlusive Arterial Disease Perfusion Index Mean Blood Pressure Peripheral Perfusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • G. Cicco
    • 1
  • A. J. van der Kleij
    • 2
  • G. D. Stingi
    • 1
  • M. S. Tarallo
    • 1
  • A. Pirrelli
    • 1
  1. 1.Department of Clinical Methodology and Medico-Surgical Technologies Internal Medicine and Hypertension Lab. of Hemorheology and Oxygen Transport to TissueUniversity of BariItaly
  2. 2.Department of Surgery/Hyperbaric MedicineAcademic Medical Center, University of AmsterdamNetherlands

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