Norepinephrine vs Nitric Oxide Synthase Inhibition in Endotoxemia

  • Klaus Wagner
  • Reiner Schäfer
  • Angela Roth-Isigkeit
  • Karl-F. Klotz
  • Hans-Jürgen Friedrich
  • Peter Schmucker
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 471)


The mortality rate in sepsis reemains high despite many therapeutic efforts. Initial treatment of sepsis, in addition to surgical treatment of the underlying cause, is aimed to prevent circulatory shock leading to multiple organ failure, including liver failure. Therefore, vasopressor agents such as norepinephrine (NE) are frequently administered to restore vascular tone and improve tissue perfusion (Vincent et al., 1991).


Mean Arterial Pressure Blood Lactate Level Circulatory Shock Organ Blood Flow Hyperdynamic State 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Klaus Wagner
    • 1
  • Reiner Schäfer
    • 1
  • Angela Roth-Isigkeit
    • 2
  • Karl-F. Klotz
    • 1
  • Hans-Jürgen Friedrich
    • 2
  • Peter Schmucker
    • 2
  1. 1.Department of AnesthesiologyMedical University LübeckGermany
  2. 2.Institut für medizinische Biometrie und StatistikMedical University LübeckGermany

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