Norepinephrine vs Nitric Oxide Synthase Inhibition in Endotoxemia
The mortality rate in sepsis reemains high despite many therapeutic efforts. Initial treatment of sepsis, in addition to surgical treatment of the underlying cause, is aimed to prevent circulatory shock leading to multiple organ failure, including liver failure. Therefore, vasopressor agents such as norepinephrine (NE) are frequently administered to restore vascular tone and improve tissue perfusion (Vincent et al., 1991).
KeywordsCatheter Lactate Norepinephrine Fentanyl Ketamine
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- Burton RG and Gorewit RC: Ultrasonic flowmeter uses wide-beam transit-time technique. Med Elec 1984; 34:68–73.Google Scholar
- Kilbourn RG, Jubran A, Gross SS, Griffith OW, Levi R, Adams J, and Lodato RF: Reversal of endotoxin-mediated shock by B-methyl-1-arginine, an inhibitor of nitric oxide synthesis. Biochem Biophys Res Commun 1990; 172:l 132–1138.Google Scholar
- Lang Ch, Bagby GJ, Ferguson JL, and Spitzer JJ: Cardiac output and redistribution of organ blood flow in hypermetabolic sepaia. Am J Physiol 1984; 246:331–337.Google Scholar
- Nöldge GFE, Pannen BHJ, Armbruster K, and Gelger KK: Endotoxemia induces more profound impairment of small intestinal than of hepatic oxygenation in pigs. Anaesthesiology 1993; 79:A253.Google Scholar
- Nöldge GFE, Armbruster K, Pannen BHJ, Müller W, and Gelger KK: Changes in intestinal mucosal pH during endotoxemia are not necessarily reflected in respective changes in splanchnic metabolic and acid-base status. Anaesthesiology 1993; 79:A761.Google Scholar
- Pohl U, Wagner K, and De Witt C: Endothelium-derived nitric oxide in the control of tissue perfusion and oxygen supply: physiological and pathophysiological implications. Europ Heart J 1993;14(S I):93–98.Google Scholar
- Schramm U, Wagner K, Bossen W, and Weiss C: PO2 Messung mit einem neuen Sauerstoffsensor: Morphologische Veränderungen im Bereich des Stichkanals. Anat Anz 1992; 174:78–81.Google Scholar