Abstract
When blood flows through the lungs, O2 uptake causes unbinding of chemically bound CO2, and contributes by this mechanism to CO2 release from blood into pulmonary alveoli. This O2-linked alveolar CO2 discharge is thus a consequence of the Haldane effect (HE), a relatively well-known phenomenon (Christiansen et al., 1914). However, its magnitude and the relative respiratory implications are not recognized or quantified commonly, due to the lack of easily suitable methods. Our study has been carried out to perform such an assessment over a large group of patients, based on a previously validated model for blood CO2 exchange and CO2-O2 interactions (Giovannini et al., 1993), and to develop new relationships which may ease quantification of the phenomenon in theoretical, experimental and clinical settings.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Christiansen J, Douglas CG, and Haidane GS (1914) The absorption and dissociation of carbon dioxide by human blood. J Physiol 48:244–271.
Comroe JH jr, Forster RE, Du Bois AB, Briscoe WA, and Carlsen E (1962) In: The Lung, Chicago, Year Book.
Du Bois D and Du Bois EF (1916) A formula to estimate the approximate surface area if height and weight be known. Arch Int Med 17:863–871.
Elebute EA and Stoner HB (1983) The grading of sepsis. Br J Surg 70:29–31.
Giovannini I, Chiarla C, Boldrini G, and Castagneto M (1989) Impact of fat and glucose administration on metabolic and respiratory interactions in sepsis. JPEN 13:141–146.
Giovannini I, Chiarla C, Boldrini G, and Castagneto M (1993) Calculation of venoarterial CO2 concentration difference. J Appl Physiol 74:959–964.
Grant BJB (1982) Influence of Bohr-Haldane effect on steady-state gas exchange. J Appl Physiol 52:1330–1337.
Hicks JW and White FN (1992) Pulmonary gas exchange during intermittent ventilation in the American alligator. Respir Physiol 88:23–36.
Joffe J and Poulton EP (1921) The partition of CO2 between plasma and corpuscles in oxygenated and reduced blood. J Physiol 54:129–151.
Kelman GR (1968) Nomogram for calculation of buffer line shift due to reduction of haemoglobin at constant PCO2. Clin Chim Acta 22:277–280.
Klocke RA (1987) Carbon dioxide transport. In: Handbook of Physiology, The Respiratory System, Vol. 4 (Farhi LE, Marsh Tenney S, Eds), American Physiological Society, Bethesda MD, pp. 173–197.
Mertzlufft F and Brandt L (1989) An in vivo model for the proof of the Christiansen-Douglas-Haldane effect. In: Oxygen Transport to Tissue, XI (Rakusan K, Biro GP, Goldstick TK, Turek Z, Eds), Plenum Press, New York, pp. 397–405.
Mithoefer JC (1959) Mechanism of pulmonary gas exchange and CO2 transport during breath holding. J Appl Physiol 14:706–710.
Nahas GG and Verosky M (1966) The storage of CO2 during apneic oxygenation. Ann NY Acad Sci 133:134–141.
Seber GAF (1977) In: Linear Regression Analysis, New York Wiley.
Stadie WC and O’Brien H (1937) The carbamate equilibrium. II. The equilibrium of oxyhemoglobin and reduced hemoglobin. J Biol Chem 117:439–470.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1999 Springer Science+Business Media New York
About this chapter
Cite this chapter
Giovannini, I. et al. (1999). Easy Quantification of the Respiratory and Metabolic Impact of Blood O2-CO2 Exchange Interactions in Critical Illness. In: Eke, A., Delpy, D.T. (eds) Oxygen Transport to Tissue XXI. Advances in Experimental Medicine and Biology, vol 471. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4717-4_47
Download citation
DOI: https://doi.org/10.1007/978-1-4615-4717-4_47
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-7137-3
Online ISBN: 978-1-4615-4717-4
eBook Packages: Springer Book Archive