Role of Nitric Oxide in the Control of Mitochondrial Function
Nitric oxide (NO) has been a focus of intense scientific investigation over the past years. A vast array of physiologic as well as pathophysiologic roles for NO have been described in pulmonary, immunologic, neuronal, gastrointestinal, and reproductive systems.21 Undoubtedly however, the preponderance of nitric oxide research has focused on the role of NO in the cardiovascular system, both in normal and pathophysiologic states. Nitric oxide is involved in the control of mean arterial blood pressure, vascular tone and regional blood flow in virtually all vascular beds.1,34 In addition, NO prevents platelet aggregation and is an inhibitor of vascular smooth muscle proliferation. Thus, NO is believed to contribute significantly to the maintenance of vascular homeostasis. Despite ample evidence in support of the action of NO on vascular smooth muscle and the local abluminal environment, the role of NO in the control of tissue oxygen consumption has received relatively little attention. Thus, this chapter will discuss the role of NO in the control of tissue respiration, as well as possible physiologic and pathophysiologic implications linking endogenous NO production and oxygen utilization in mammalian systems.
KeywordsPlacebo Permeability Ischemia Superoxide Respiration
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