Role of Nitric Oxide in the Control of Mitochondrial Function
Nitric oxide (NO) has been a focus of intense scientific investigation over the past years. A vast array of physiologic as well as pathophysiologic roles for NO have been described in pulmonary, immunologic, neuronal, gastrointestinal, and reproductive systems.21 Undoubtedly however, the preponderance of nitric oxide research has focused on the role of NO in the cardiovascular system, both in normal and pathophysiologic states. Nitric oxide is involved in the control of mean arterial blood pressure, vascular tone and regional blood flow in virtually all vascular beds.1,34 In addition, NO prevents platelet aggregation and is an inhibitor of vascular smooth muscle proliferation. Thus, NO is believed to contribute significantly to the maintenance of vascular homeostasis. Despite ample evidence in support of the action of NO on vascular smooth muscle and the local abluminal environment, the role of NO in the control of tissue oxygen consumption has received relatively little attention. Thus, this chapter will discuss the role of NO in the control of tissue respiration, as well as possible physiologic and pathophysiologic implications linking endogenous NO production and oxygen utilization in mammalian systems.
KeywordsNitric Oxide Septic Shock Cytochrome Oxidase Mitochondrial Respiration Myocardial Oxygen Consumption
Unable to display preview. Download preview PDF.
- 1.Bevan, JA, G Kaley, and GM Rubanyi. Flow dependent regulation of vascular function PP 163-177, Oxford University Press, 1995.Google Scholar
- 6.Elkayam, U, J Amin, A Mehra, J Vasquez, L Weber, and SH Rahimtoola. A prospective, randomized double-blind, crossover study to compare the efficacy and safety of chronic nifedipine therapy with that of isosorbide dinitrate and their combination in the treatment of chronic congestive heart failure. Circulation 82:1954–1961, 1990.PubMedCrossRefGoogle Scholar
- 9.Forfia, PR, X Zhang, D Knight, MS Wolin, and TH Hintze. The role of nitric oxide in the modulation of myocardial oxygen consumption in the non-human primate; an alternative mechanism of action for a calcium channel blocker. Submitted, 1998.Google Scholar
- 22.Okada, S, Y Takehara, M Yabaki, T Yoshioka, T Yasuda, M Inoue, and K Utsumi. Nitric oxide, a physiological modulator of mitochondrial function. Physiol. Chem. Phys. and Med. N MR 28:69–82, 1996.Google Scholar
- 38.Yonetani, T, JE Erman, JS Leigh, and GH Reed. Electromagnetic properties of hemoproteins. J. of Biol. Chem. 247(8):2447–2455, 1972.Google Scholar