Hypoxia pp 79-79 | Cite as

High Altitude Pulmonary Edema

  • Peter Bärtsch
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 474)


The aim of this section is to present the latest results on HAPE research and to discuss their implications for understanding the pathophysiology of HAPE. Although high pulmonary artery pressure appears to be a condition ‘sine qua non’ it is not clear what causes the exaggerated pressure response and how it accounts for the leak. Animal models and findings in bronchoalveolar lavage fluid indicate a role for increased permeability due to inflammation. Furthermore, data obtained in cell cultures suggest that hypoxia may reduce fluid clearance from the alveoli. Simon Gibbs will review the data on pulmonary circulation in HAPE-susceptible subjects and discuss hemodynamic concepts. Urs Scherrer will evaluate a possible role of transepithelial sodium transport on edema formation and present data obtained in vivo supporting the hypothesis of decreased alveolar fluid clearance in HAPE.

Key words

pulmonary circulation alveolar fluid clearance transepithelial sodium clearance pulmonary hypertension pulmonary artery pressure 

Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Peter Bärtsch
    • 1
  1. 1.Department of Sports MedicineRupprecht Karls UniversityHeidelbergGermany

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