A Tribute to Niels Lassen
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Niels Lassen died in Copenhagen of pancreatic carcinoma at 71. He was the premier leader in the field of quantitation of cerebral blood flow (CBF). Immediately after finishing medical school, he and Ole Munck introduced the use of radioactive isotopes for CBF measurement. With David Ingvar, he was the first to use collimated radioactive extracranial counting after intracarotid injection of the radioactive isotope 85Krypton or 133Xenon dissolved in saline to localize regions of high or low cerebral flow. His mathematician wife Edda Sveinsdotter developed programming methods and much technical support. Functional brain mapping was pioneered by Lassen using, finally, a 254 detector system. With Bo Siesjo and David Ingvar, he founded the International Cerebral Blood Flow meetings and later the Journal of Cerebral Blood Flow and Metabolism. From 1962 to 1996 he was chairman of the department of clinical physiology and nuclear medicine at Bispebjerg Hospital in Copenhagen. Niels’ command of English was better than mine, elegant, witty and creative. The terms “luxury perfusion” and “ischemic penumbra” are his.
Key wordscerebral blood flow
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- Friberg, L., J. Kastrup, D. Rizzi, J. B. Jensen, and N. A. Lassen. Cerebral blood flow and end-tidal PCO2 during prolonged acetazolamide treatment in humans. Am JPhysiol 258: H954–9, 1990.Google Scholar
- Jensen, J. B., B. Sperling, J. W. Severinghaus, and N. A. Lassen. Augmented hypoxic cerebral vasodilation in men during 5 days at 3,810 m altitude. J Appl Physiol 80: 1214–8, 1996.Google Scholar
- Vorstrup, S., K. E. Jensen, C. Thomsen, O. Henriksen, N. A. Lassen, and O. B. Paulson. Neuronal pH regulation: constant normal intracellular pH is maintained in brain during low extracellular pH induced by acetazolamide--31P NMR study. J Cereb Blood Flow Metab 9: 417–21, 1989.PubMedCrossRefGoogle Scholar